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Control of Invasive Cell Growth by the Met Family Oncogenes

  • Chapter
Cancer Genes

Part of the book series: Pezcoller Foundation Symposia ((PFSO,volume 7))

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Abstract

The Hepatocyte Growth Factor receptor, encoded by the MET proto-oncogene (Naldini et al., 1991b, 1991c; Bottaro et al., 1991), is the prototype of a growing family of tyrosine kinases whose members share structural features of crucial functional relevance. Recently, two molecules have joined the family: the RON and the SEA gene products (Ronsin et al., 1993; Huff et al., 1993; Gaudino et al., 1994). Interestingly, the Ron protein was shown to be the specific receptor for Macrophage Stimulating Protein (MSP), a growth factor highly homologous to Hepatocyte Growth Factor (Gaudino et al., 1994; Wang et al., 1994). Therefore, the ligands for receptors of the MET family form a family themselves (the “HGF family”). So far, the ligand for the putative receptor encoded by the SEA proto-oncogene is elusive.

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  1. Institute for Cancer Research and Treatment (I.R.C.C.), University of Torino School of Medicine, Italy

    Francesco Galimi & Paolo M. Comoglio

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  1. Francesco Galimi
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  2. Paolo M. Comoglio
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  1. Roswell Park Cancer Institute, Buffalo, New York, USA

    Enrico Mihich

  2. MIT Center for Cancer Research, Cambridge, Massachusetts, USA

    David Housman

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Galimi, F., Comoglio, P.M. (1996). Control of Invasive Cell Growth by the Met Family Oncogenes. In: Mihich, E., Housman, D. (eds) Cancer Genes. Pezcoller Foundation Symposia, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5895-8_2

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  • DOI: https://doi.org/10.1007/978-1-4615-5895-8_2

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