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Cancer Genes pp 177–191Cite as

Retinoblastoma Protein, Gene Expression, and Cell Cycle Control

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Part of the book series: Pezcoller Foundation Symposia ((PFSO,volume 7))

Abstract

Regulation of cell proliferation is achieved by the tight control of the progression through the cell cycle which controls the transition of cells between quiescent and growing states. This regulation relies on the coordinated balance between inhibitory and stimulatory signals. The stimulatory factors (e.g., growth factors) and their receptors are often encoded by a class of genes called proto-oncogenes. Cells also contain several inhibitory proteins, encoded by tumor suppressor genes which act as either censors or pacers (Marx, 1994).

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  1. David Jensen

    Present address: Wistar Institute, 36th and Spruce Streets, Philadelphia, PA, 19104, USA

Authors and Affiliations

  1. Department of Experimental Therapeutics Grace Cancer Drug Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York, 14263, USA

    Jane Clifford Azizkhan, Shiaw Yih Lin, Dusan Kostic & Adrian R. Black

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  1. Roswell Park Cancer Institute, Buffalo, New York, USA

    Enrico Mihich

  2. MIT Center for Cancer Research, Cambridge, Massachusetts, USA

    David Housman

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Azizkhan, J.C., Lin, S.Y., Jensen, D., Kostic, D., Black, A.R. (1996). Retinoblastoma Protein, Gene Expression, and Cell Cycle Control. In: Mihich, E., Housman, D. (eds) Cancer Genes. Pezcoller Foundation Symposia, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5895-8_10

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