Abstract
The carotid chemoreceptors are important in the neonate for maturation of normal cardiorespiratory control and for survival of the neonatal period. Critically important features of normal respiratory control —such as recovery from apnea, ventilatory defense during hypoxic stress, arousal from sleep during hypoxemia or upper airway obstruction, and development of normal breathing patterns during postnatal maturation— all depend on the carotid chemoreceptors. Current evidence suggests involvement of the carotid chemoreceptors in a variety of neonatal disorders including high mortality rates in infants with bronchopulmonary dysplasia, severe bradycardia during hypoxemia, and the sudden infant death syndrome (SIDS).
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References
Blanco CE, Dawes GS, Hanson MA & McCooke HB (1984) The response to hypoxia of arterial chemoreceptors in fetal sheep and newborn lambs. J Physiol, London 351: 25–37
Blanco CE, Hanson MA & McCooke HB (1988) Effects on carotid chemoreceptor resetting of pulmonary ventilation in the fetal lamb in utero. J Dev Physiol 10: 167–174
Bureau MA, Lamarche J, Foulon P & Dalle D (1985) Postnatal maturation of respiration in intact and carotid body-chemodenervated lambs. J Appl Physiol 59: 869–874
Carroll JL, Bamford OS & Fitzgerald RS (1993) Postnatal maturation of carotid chemoreceptor responses to O2 and CO2 in the cat. J Appl Physiol 75: 2383–2391
Donnelly DF & Haddad GG (1990) Prolonged apnea and impaired survival in piglets after sinus and aortic nerve section. J Appl Physiol 68: 1048–1052
Eden GJ & Hanson MA (1987) Effects of chronic hypoxia from birth on the ventilatory response to acute hypoxia in the newborn rat. J Physiol, London 392: 11–19
Frappell P, Saiki C & Mortola JP (1991) Metabolism during normoxia, hypoxia and recovery in the newborn kitten. Respir Physiol 86: 115–124
Hanson MA, Kumar P & Williams BA (1989) The effect of chronic hypoxia upon the development of respiratory chemoreflexes in the newborn kitten. J Physiol, London 411: 563–574
Hertzberg T, Hellström S, Holgert H, Lagercrantz H & Pequignot JM (1992) Ventilatory response to hyperoxia in newborn rats born in hypoxia — possible relationship to carotid body dopamine. J Physiol, London 456: 645–654
Hofer MA (1986) Role of carotid sinus and aortic nerves in respiratory control of infant rats. Am J Physiol 251: R811–R817
Kholwadwala D & Donnelly DF (1992) Maturation of carotid chemoreceptor sensitivity to hypoxia: in vitro studies in the newborn rat. J Physiol, London 453: 461–473
Kumar P & Hanson MA (1989) Re-setting of the hypoxic sensitivity of aortic chemoreceptors in the new-born lamb. J Dev Physiol 11: 199–206
Lawson EE & Long WA (1983) Central origin of biphasic breathing pattern during hypoxia in newborns. J Appl Physiol 55: 483–488
Marchal F, Bairam A, Haouzi P, Crance JP, Di-Giulio C, Vert P & Lahiri S (1992) Carotid chemoreceptor response to natural stimuli in the newborn kitten. Respir Physiol 87: 183–193
Martin-Body RL (1988) Brain transections demonstrate the central origin of hypoxic ventilatory depression in carotid body-denervated rats. J Physiol, London 407: 41–52
Mortola JP, Rezzonico R & Lanthier C (1989) Ventilation and oxygen consumption during acute hypoxia in newborn mammals: a comparative analysis. Respir Physiol 78: 31–43
Mulligan EM (1991). Discharge properties of carotid bodies: Developmental aspects. In: Haddad GG & Färber JP (eds) Developmental Neurobiology of Breathing. New York: Marcel Dekker. pp 321–340
Sterni LM, Bamford OS, Tomares SM, Montrose MH & Carroll JL (1995) Developmental changes in intracellular Ca2+ response of carotid chemoreceptor cells to hypoxia. Am J Physiol 268: L801–L808
Tomares SM, Bamford OS, Sterni LM, Fitzgerald RS & Carroll JL (1994) Effects of domperidone on neonatal and adult carotid chemoreceptors in the cat. J Appl Physiol 77: 1274–1280
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© 1996 Springer Science+Business Media New York
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Carroll, J.L., Sterni, L.M., Bamford, O.S., Montrose, M.H. (1996). Mechanisms of Carotid Chemoreceptor Resetting after Birth. In: Zapata, P., Eyzaguirre, C., Torrance, R.W. (eds) Frontiers in Arterial Chemoreception. Advances in Experimental Medicine and Biology, vol 410. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5891-0_9
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DOI: https://doi.org/10.1007/978-1-4615-5891-0_9
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