Abstract
Guinea-pigs have a normal, possibly accentuated, hyperventilatory response to hypercapnia whereas that to hypoxia is delayed and extremely blunted (Blake & Banchero, 1985a,b; Alarie & Stock, 1988; Cragg & Menzies, 1992; Peebles & Cragg, 1995). Although these Guinea-pigs are low altitude dwellers, their breathing responses are typical of small mammals and humans adapted to high altitude (Monge & Leon-Velarde, 1991), where the adaptation is termed phenotypic because it requires prior exposure to long-term hypoxia. As Guinea-pigs originated some centuries ago from the high altitude habitats of South America, it is tempting to ask whether they have retained a genotypic adaptation to high altitude. The mechanism(s) responsible for the blunted ventilatory response to hypoxia in other mammals is controversial; much of the evidence indicates involvement of the carotid bodies (Bisgard & Neubauer, 1995).
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© 1996 Springer Science+Business Media New York
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Cragg, P.A., Schwenke, D.O. (1996). Role of Carotid Bodies in the Guinea-Pig. In: Zapata, P., Eyzaguirre, C., Torrance, R.W. (eds) Frontiers in Arterial Chemoreception. Advances in Experimental Medicine and Biology, vol 410. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5891-0_58
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DOI: https://doi.org/10.1007/978-1-4615-5891-0_58
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