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Augmented Ventilatory Response to Sustained Normocapnic Hypoxia Following 100% O2 Breathing in Humans

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Frontiers in Arterial Chemoreception

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 410))

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Abstract

The presence of hyperoxic hyperventilation seems to have been well confirmed in humans by Becker et al (1995) when the PETco2 is maintained at a normocapnic level. They also observed that augmented ventilation at higher than the control level still continued even 15 min after termination of hyperoxia, suggesting that a humoral agent might be involved to stimulate ventilation.

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References

  • Bascom DA, Clements ID, Cunningham DA, Painter R & Robbins PA (1990) Changes in peripheral chemoreflex sensitivity during sustained isocapnic hypoxia. Respir Physiol 62: 161–176

    Article  Google Scholar 

  • Becker H, Polo O, McNamara SG, Berthon-Jones M & Sullivan CE (1995) Ventilatory response to isocapnic hy-peroxia. J Appl Physiol 78: 696–701

    PubMed  CAS  Google Scholar 

  • Easton PA, Slykerman LJ & Anthonisen NR (1986) Ventilatory response to sustained hypoxia in normal adults. J Appl Physiol 61: 906–911

    PubMed  CAS  Google Scholar 

  • Gautier H, Bonora HM & Gaudy JH (1986) Ventilatory response of the conscious or anesthetized cat to oxygen breathing. Respir Physiol 65: 181–196

    Article  PubMed  CAS  Google Scholar 

  • Hamberger AC, Chiang GH, Nylen ES, Schelf SW & Cotman CW (1979) Glutamate as a CNS transmitter. I. Evaluation of glucose and glutamine as precursors for the synthesis of preferentially released glutamate. Brain Res 168:513–530

    Article  PubMed  CAS  Google Scholar 

  • Kazemi H & Hoop B (1991) Glutamic acid and γ-aminobutyric acid neurotrasmitters in central control of breathing. J Appl Physiol 70: 1–7

    Article  PubMed  CAS  Google Scholar 

  • Li A & Nattie EE (1995) Prolonged stimulation of respiration by brain stem metabotropic glutamate receptors. J Appl Physiol 79: 1650–1656

    PubMed  CAS  Google Scholar 

  • Miller MJ & Tenney SM (1975) Hyperoxic hyperventilation in carotid-deafferented cats. Respir Physiol 23: 23–30

    Article  PubMed  CAS  Google Scholar 

  • Nattie EE, Li A & St John WM (1991) Lesions in retrotrapezoid nucleus decrease ventilatory output in anesthetized or decerebrate cats. J Appl Physiol 71:1364–1375

    PubMed  CAS  Google Scholar 

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© 1996 Springer Science+Business Media New York

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Honda, Y. et al. (1996). Augmented Ventilatory Response to Sustained Normocapnic Hypoxia Following 100% O2 Breathing in Humans. In: Zapata, P., Eyzaguirre, C., Torrance, R.W. (eds) Frontiers in Arterial Chemoreception. Advances in Experimental Medicine and Biology, vol 410. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5891-0_57

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  • DOI: https://doi.org/10.1007/978-1-4615-5891-0_57

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7702-3

  • Online ISBN: 978-1-4615-5891-0

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