Abstract
Secretoneurin (SN) is a 33 amino acid peptide formed by proteolysis from secretogranin II (chromogranin C) which is widely distributed in endocrine and neural tissue where it is stored in large dense-cored vesicles (see Kirchmair et al, 1993; Marksteiner et al, 1993). SN has been found in various parts of the brain, including the nucleus tractus solitarii —a region where chemoreceptor afférents terminate— and it is stored in C-fibre afferent neurons (Kirchmair et al, 1994). The association of SN with chromaffin tissue and with small diameter sensory nerves led us to hypothesise that SN is present in the carotid body, and we performed experiments in rats to test this hypothesis.
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© 1996 Springer Science+Business Media New York
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McQueen, D.S., Eder, U., Timm, M., Winkler, H., Dashwood, M.R., Bond, S.M. (1996). Secretoneurin. In: Zapata, P., Eyzaguirre, C., Torrance, R.W. (eds) Frontiers in Arterial Chemoreception. Advances in Experimental Medicine and Biology, vol 410. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5891-0_50
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DOI: https://doi.org/10.1007/978-1-4615-5891-0_50
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