Abstract
It has been proposed that the modulation of potassium channel activity by hypoxia plays a key role in oxygen sensing by the type-I cells of the carotid body. To date, two main types of oxygen-sensitive K-channels have been characterised in type-I cells. These are a high conductance (190 pS) calcium activated potassium channel (BKCa) found in rat type-I cells (Wyatt & Peers, 1995), and lower conductance (40 pS) calcium insensitive channel (termed the KO2-channel) found in rabbit type-I cells (Ganfornina & LopezBarneo, 1991). It has been suggested that inhibition of these channels by hypoxia is responsible for membrane depolarisation which in turn induces voltage-gated calcium entry and neurosecretion.
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References
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© 1996 Springer Science+Business Media New York
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Buckler, K.J. (1996). Role of Potassium Channels in Hypoxic Chemoreception in Rat Carotid Body Type-I Cells. In: Zapata, P., Eyzaguirre, C., Torrance, R.W. (eds) Frontiers in Arterial Chemoreception. Advances in Experimental Medicine and Biology, vol 410. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5891-0_11
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DOI: https://doi.org/10.1007/978-1-4615-5891-0_11
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