Inactivity Alters Structural and Functional Properties of the Neuromuscular Junction

  • Y. S. Prakash
  • Hirofumi Miyata
  • Wen-Zhi Zhan
  • Gary C. Sieck


The diaphragm (DIAm) is the most important inspiratory muscle involved in mammalian ventilation, and accordingly it has a high duty cycle (fraction of time active versus inactive; ∼40% for the rat DIAm (7, 8)), compared to limb muscles (∼2% for the soleus muscle to ∼15% for the extensor digitorum longus muscle (5)). This unique activation pattern of the DIAm might make it particularly susceptible to inactivity.


Motor Unit Nerve Terminal Neuromuscular Junction Phrenic Nerve Neuromuscular Transmission 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Y. S. Prakash
    • 1
  • Hirofumi Miyata
    • 2
  • Wen-Zhi Zhan
    • 1
  • Gary C. Sieck
    • 1
  1. 1.Departments of AnesthesiologyPhysiology and Biophysics Mayo ClinicRochesterUSA
  2. 2.Department of Exercise PhysiologyYamaguchi UniversityJapan

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