Abstract
The diaphragm (DIAm) is the most important inspiratory muscle involved in mammalian ventilation, and accordingly it has a high duty cycle (fraction of time active versus inactive; ∼40% for the rat DIAm (7, 8)), compared to limb muscles (∼2% for the soleus muscle to ∼15% for the extensor digitorum longus muscle (5)). This unique activation pattern of the DIAm might make it particularly susceptible to inactivity.
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Prakash, Y.S., Miyata, H., Zhan, WZ., Sieck, G.C. (1996). Inactivity Alters Structural and Functional Properties of the Neuromuscular Junction. In: Steinacker, J.M., Ward, S.A. (eds) The Physiology and Pathophysiology of Exercise Tolerance. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5887-3_9
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