Physiological Limitations to Endurance Exercise
Endurance performance is dependent on the coordinated responses of the cardiovascular and respiratory systems, muscle metabolism, mechanical efficiency, and thermoregulation. A number of reviews have focused on one, or several, aspects of these responses (1,7,18). Yet, one central tenet of optimizing endurance performance revolves around the efficient aerobic transformation of metabolic substrate into mechanical power output, with delayed depletion of the glycogen reserves (1,10). Thus, it is important to have an efficient oxygen transport system and a metabolic system that supplies appropriate substrates to the mitochondria for oxidative metabolism with minimal concurrent glycolysis, a concept called “tight coupling” of oxidative metabolism (14).
KeywordsBlood Lactate Endurance Training Work Rate Endurance Exercise Submaximal Exercise
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Astrand, P. and K. Rodahl. Textbook of Work Physiology
. New York: McGraw-Hill Book Co. 1985.Google Scholar
Barstow, T. J., S. Buchthal, S. Zanconato, and D. M. Cooper. Muscle energetics and pulmonary oxygen uptake kinetics during moderate exercise. J. Appl. Physiol.
: 1742–1749, 1994.PubMedGoogle Scholar
Cadefau, J., H. J. Green, R. Cussó, M. Ball-Burnett, and G. Jamieson. Coupling of muscle phosphorylation potential to glycolysis during work after short-term training. J. Appl. Physiol.
: 2586–2593, 1994.PubMedGoogle Scholar
Casaburi, R., T. W. Storer, I. Ben-Dov, and K. Wasserman. Effect of endurance training on possible determinants of VO2
during heavy exercise. J. Appl. Physiol.
: 199–207, 1987.PubMedGoogle Scholar
Connett, R. J. Analysis of metabolic control: new insights using scaled creatine kinase model. Am. J. Physiol.
: R949–R959, 1988.PubMedGoogle Scholar
Corcondilas, A., G. T. Koroxenidis, and J. T. Shepherd. Effect of a brief contraction of forearm muscles on forearm blood flow. J. Appl. Physiol.
: 142–146, 1964.PubMedGoogle Scholar
Coyle, E. F. Integration of the physiological factors determining endurance performance ability. In: Exercise and Sport Sciences Reviews
, edited by J. O. Holloszy. Baltimore: Williams and Wilkins, 1995, p. 25–63.Google Scholar
Dempsey, J. A., P. E. Hanson, and K. S. Henderson. Exercise induced arterial hypoxemia in healthy persons at sea level. J. Physiol. (Lond)
: 161–175, 1984.Google Scholar
di Prampero, P. E. and R. Margaria. Relationship between O2
consumption, high energy phosphates and the kinetics of the O2
debt in exercise. Pflugers Arch
: 11–19, 1968.PubMedCrossRefGoogle Scholar
Green, H. J. How important is endogenous muscle glycogen to fatigue in prolonged exercise. Can. J. Physiol. Pharmacol.
: 2971991.Google Scholar
Green, H. J., J. Cadefau, R. Cussö, M. Ball-Burnett, and G. Jamieson. Metabolic adaptations to short term training are expressed early in submaximal exercise. Can. J. Physiol. Pharmacol.
: 474–482, 1995.PubMedCrossRefGoogle Scholar
Green, H. J., S. Jones, M. E. Ball-Burnett, D. Smith, J. Livesey, and B. W. Farrance. Early muscular and metabolic adaptations to prolonged exercise training in humans. J. Appl. Physiol.
: 2032–2038, 1991.PubMedGoogle Scholar
Hickson, R. C., H. A. Bomze, and J. O. Holloszy. Faster adjustment of O2
uptake to the energy requirement of exercise in the trained state. J. Appl. Physiol.
: 877–881, 1978.PubMedGoogle Scholar
Hochachka, P. W. and G. O. Matheson. Regulating ATP turnover rates over broad dynamic work ranges in skeletal muscles.J. Appl. Physiol.
: 1697–1703, 1992.PubMedGoogle Scholar
Hughson, R. L. Alterations in the oxygen deficit-oxygen debt relationships with beta-adrenergic receptor blockade in man. J. Physiol. (London)
: 375–387, 1984.Google Scholar
Hughson, R. L. and M. A. Morrissey. Delayed kinetics of VO2
in the transition from prior exercise. Evidence for O2
transport limitation of VO2
kinetics. A review. Int. J. Sports Med.
: 94–105, 1983.Google Scholar
Hughson, R. L., H. C. Xing, J. E. Cochrane, and G. C. Butler. Faster increase in oxygen uptake during supine exercise with lower body negative pressure. J. Appl. Physiol.
: 1962–1967, 1993.PubMedGoogle Scholar
Joyner, M. J. Physiological limiting factors and distance running: Influence of gender and age on record performances. In: Exercise and Sport Sciences Reviews
, edited by J. O. Holloszy. Baltimore: Williams and Wilkins, 1993, p. 103–133.Google Scholar
Leyk, D., D. Eβfeld, K. Baum, and J. Stegemann. Early leg blood flow adjustment during dynamic foot plantarflexions in upright and supine body position. Int. J. Sports Med.
: 447–452, 1994.PubMedCrossRefGoogle Scholar
Linnarsson, D. Dynamics of pulmonary gas exchange and heart rate changes at start and end of exercise. Acta Physiol. Scand
. Suppl. 415
: 1–68, 1974.Google Scholar
Linnarsson, D., J. Karlsson, L. Fagraeus, and B. Saltin. Muscle metabolites and oxygen deficit with exercise in hypoxia and hyperoxia. J. Appl. Physiol.
: 399–402, 1974.PubMedGoogle Scholar
Murphy, P. C., L. A. Cuervo, and R. L. Hughson. Comparison of ramp and step exercise protocols during hypoxic exercise in man. Cardiovasc. Res.
: 825–832, 1989.PubMedCrossRefGoogle Scholar
Oldenburg, F. A., D. W. McCormack, J. L. C. Morse, and N. L. Jones. A comparison of exercise responses in stairclimbing and cycling. J. Appl. Physiol.
: 510–516, 1979.PubMedGoogle Scholar
Phillips, S. M., H. J. Green, M. J. MacDonald, and R. L. Hughson. Progressive effect of endurance training on VO2
kinetics at the onset of submaximal exercise. J. Appl. Physiol.
79: 1914–1920, 1995.PubMedGoogle Scholar
Sheriff, D. D., L. B. Rowell, and A. M. Scher. Is rapid rise in vascular conductance at onset of dynamic exercise due to muscle pump. Am. J. Physiol. Heart Circ. Physiol.
: H1227–H1234, 1993.Google Scholar
Shoemaker, J. K., S. M. Phillips, H. J. Green, and R. L. Hughson. Faster femoral artery blood velocity kinetics at the onset of exercise following training. Cardiovasc. Res.
in press, 1996.Google Scholar
Sun, D., A. Huang, A. Koller, and G. Kaley. Short-term daily exercise activity enhances endothelial NO synthesis in skeletal muscle arterioles of rats. J. Appl. Physiol.
: 2241–2247, 1994.PubMedGoogle Scholar
Toska, K. and M. Eriksen. Peripheral vasoconstriction shortly after onset of moderate exercise in humans. J. Appl. Physiol.
: 1519–1525, 1994.PubMedGoogle Scholar
Whipp, B. J. and M. Mahler. Dynamics of pulmonary gas exchange during exercise. In: Pulmonary Gas Exchange
, edited by J. B. West. New York: Academic, 1980, p. 33–96.Google Scholar
Yoshida, T. and H. Watari. 31
P-Nuclear magnetic resonance spectroscopy study of the time course of energy metabolism during exercise and recovery. Eur. J. Appl. Physiol.
: 494–499, 1993.CrossRefGoogle Scholar
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