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Cardiovascular and Metabolic Responses to Exercise in Heart Transplanted Children

  • C. Marconi
  • M. Marzorati
  • R. Fiocchi
  • F. Mamprin
  • P. Ferrazzi
  • G. Ferretti
  • P. Cerretelli
Chapter
  • 172 Downloads

Abstract

Heart transplantation has become an accepted therapy for end-stage congestive heart failure not only in adults but also in children (P-HTR), particularly following improvements in the immunosuppressive regimens. However, little is known about the structural evolution of the allograft or its adaptive response to increased metabolic demand. Normal growth of the allograft is especially important in P-HTR, since the possibility to undergo cardiac development commensurate to the increase in body size is essential for the normal physical performance of these patients (10). In addition, adequate growth may hypothetically be associated with some form of cardiac reinnervation, which, as is well known, does not occur in adults. So far, however, experimental evidence of sinus node reinnervation is lacking even for P-HTR. In fact, a study by Hsu et al. (2) has shown that the heart rate (HR) response to graded exercise of P-HTR is similar to that of adult HTR (A-HTR).

Keywords

Peak Heart Rate Pediatric Heart Transplantation Voluntary Exhaustion Blunt Heart Rate Response Sympathetic Reinnervation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • C. Marconi
    • 1
  • M. Marzorati
    • 1
  • R. Fiocchi
    • 2
  • F. Mamprin
    • 2
  • P. Ferrazzi
    • 2
  • G. Ferretti
    • 3
  • P. Cerretelli
    • 3
  1. 1.I.T.B.A. Section of PhysiologyNational Research CouncilMilanoItaly
  2. 2.Department of Cardiovascular SurgeryOspedali RiunitiBergamoItaly
  3. 3.Department of PhysiologyC.M.U., University of GenevaSwitzerland

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