Exercise Tolerance and Impairment of Sympathetic Nervous System Activity

  • Manfred J. Lehmann
  • Uwe Gastmann


The activity of the peripheral sympathetic nervous system can be evaluated based on its influence on the organism as a whole; in terms, for example, of the blood pressure and heart rate responses. Because of the complex regulation of these variables, however, such an approach remains problematic. The evaluation of sympathetic activity can be more reliably based on an analysis of plasma and urinary catecholamine profiles (17-19,31,35). This approach is justified on the basis of correlations that have been demonstrated (i) between the heart rate responses to sympathetic stimulation and the release of endogenous catecholamines into the coronary sinus of the dog (40), and (ii) between sympathetic activity in sympathetic fibers of peripheral nerves, recorded with microelectrodes, and the venous noradrenaline concentration of the respective extremity (38).


Sympathetic Activity Heart Rate Response Plasma Catecholamine Sympathetic Nervous System Activity Plasma Catecholamine Level 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Manfred J. Lehmann
    • 1
  • Uwe Gastmann
    • 1
  1. 1.Department of Sports and Performance MedicineMedical University Hospital UlmUlmGermany

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