Intracoronary Blockade of Nitric Oxide Synthetase Limits Coronary Vasodilation During Submaximal Exercise
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The vascular endothelium is important in modulating vasomotor tone (1,3). Among the important vasoactive substances synthesized by endothelial cells is endothelium-derived relaxing factor or nitric oxide (NO), which is synthesized from the amino acid L-arginine and catalyzed by nitric oxide synthase (16,33) in response to many stimuli including flow-induced shear stress at the interface between blood and the endothelial cell surface (7,8). This flow-dependent control seems to be important in the coronary circulation due to the extremely pulsatile nature of flow patterns in this vascular bed.
KeywordsNitric Oxide Nitric Oxide Coronary Blood Flow Submaximal Exercise Coronary Vasodilation
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