Abstract
The vascular endothelium is important in modulating vasomotor tone (1,3). Among the important vasoactive substances synthesized by endothelial cells is endothelium-derived relaxing factor or nitric oxide (NO), which is synthesized from the amino acid L-arginine and catalyzed by nitric oxide synthase (16,33) in response to many stimuli including flow-induced shear stress at the interface between blood and the endothelial cell surface (7,8). This flow-dependent control seems to be important in the coronary circulation due to the extremely pulsatile nature of flow patterns in this vascular bed.
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Gwirtz, P.A., Kim, SJ. (1996). Intracoronary Blockade of Nitric Oxide Synthetase Limits Coronary Vasodilation During Submaximal Exercise. In: Steinacker, J.M., Ward, S.A. (eds) The Physiology and Pathophysiology of Exercise Tolerance. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5887-3_21
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