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Intracoronary Blockade of Nitric Oxide Synthetase Limits Coronary Vasodilation During Submaximal Exercise

  • Patricia A. Gwirtz
  • Sung-Jung Kim
Chapter

Abstract

The vascular endothelium is important in modulating vasomotor tone (1,3). Among the important vasoactive substances synthesized by endothelial cells is endothelium-derived relaxing factor or nitric oxide (NO), which is synthesized from the amino acid L-arginine and catalyzed by nitric oxide synthase (16,33) in response to many stimuli including flow-induced shear stress at the interface between blood and the endothelial cell surface (7,8). This flow-dependent control seems to be important in the coronary circulation due to the extremely pulsatile nature of flow patterns in this vascular bed.

Keywords

Nitric Oxide Nitric Oxide Coronary Blood Flow Submaximal Exercise Coronary Vasodilation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Amrani, J.O., N.J. Allen, S.E. Harding, J. Jayakumar, J.R. Pepper, S. Monaca, and M.H. Yacoub. Role of basal release of nitric oxide on coronary flow and mechanical performance of the isolated rat heart. J. Physiol. 456:681-687, 1992.Google Scholar
  2. 2.
    Berdeaux, A, B. Ghaleh, J.L. Dubois-Rande, B. Vigue, C.D.L. Rochelle, L. Hittinger, and J.F. Giudicelli. Role of vascular endothelium in exercise-induced dilation of large epicardial coronary arteries in conscious dogs. Circ. 89:2799–2808, 1994.Google Scholar
  3. 3.
    Brenner B.M., J.L. Troy, and B.J. Ballermann. Endothelium-dependent vascular responses: mediators and mechanisms. J. Clin. Invest. 84:1373–1378, 1989.Google Scholar
  4. 4.
    Chu, A., D.E. Chamvers, C.-C. Lin, W.D. Kuehl, R.M.J. Palmer, S. Moncada, and F.R. Cobb. Effect of inhibition of nitric oxide formation on basal vasomotion and endothelium-dependent responses of the coronary arteries in awake dogs. J. Clin. Invest. 87:1964–1968, 1991.Google Scholar
  5. 5.
    Feigl, E.O. Coronary physiology. Physiol. Rev. 65:1–205, 1983.Google Scholar
  6. 6.
    Pohl U., J. Holtz, and E. Bassenge. Crucial role of endothelium in the vasodilator responses to increased flow in vivo. Hypertension 8:21–44, 1986.Google Scholar
  7. 7.
    Rubanyi R.M., J.C. Romero, and R.M. Vanhoutte. Flow-induced release of endothelium-derived relaxing factor. Am. J. Physiol. 250:H1145–1149, 1986.Google Scholar
  8. 8.
    Shen, W, M. Lundborg, J. Wang, J.M. Stewart, X. Xu, M. Ochoa, and T.H. Hintze. Role of EDRF in regulation of regional blood flow and vascular resistance at rest and during exercise in conscious dogs. J. Appl. Physiol. 77:165–172, 1994.Google Scholar
  9. 9.
    Tipton, C. M., R. A. Carey, W. C. Easten, and H.H. Erickson. A submaximal test for dogs: evaluation of effects of training, detraining and cage refinement. J. Appl. Physiol. 37:271–215, 1974.Google Scholar
  10. 10.
    Vanhoutte, P.M. Endothelium and control of vascular function. Hypertension 13:658–667, 1989.Google Scholar
  11. 11.
    Weyrich, A. S., X. Ma, M. Buerke, T. Murohara. V. E. Armstead, A.M. Lefer, J. M. Nicolas, A. P. Thomas, D. J. Lefer, and J. Vinten-Johansen. Physiological concentrations of nitric oxide do not elicit an acute negative inotropic effect in unstimulated cardiac muscle. Circ. Res. 75:692–700, 1994.Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Patricia A. Gwirtz
    • 1
  • Sung-Jung Kim
    • 1
  1. 1.Department of Integrative PhysiologyUniversity of North Texas Health Science Center at Fort WorthFort WorthUSA

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