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Phospholipase D

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Frontiers in Bioactive Lipids

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Abstract

Phospholipase D (PLD) is a ubiquitous enzyme that hydrolyses mainly phosphatidylcholine (PC) to yield phosphatidic acid (PA) and choline. It is regulated by a variety of hormones, neurotransmitters, growth factors, cytokines and related molecules and is believed to play a role in signal transduction in many cell types. The signalling molecule produced by PLD is considered to be PA since resting levels of choline are high in most cells.

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References

  • Anthes, J.C., Wang, P., Siegel, M.I., Egan, R.W., and Billah, M.M., 1991, Granulocyte phospholipase D is activated by a guanine nucleotide dependent protein factor, Biochem. Biophys. Res. Commun. 175:236.

    Article  PubMed  CAS  Google Scholar 

  • Bagrodia, S., Taylor, S.J., Creasy, C.L., Chernoff, J., and Cerione, R.A., 1995, Identification of a mouse p32Cdc42/Rac activated kinase, J. Biol. Chem. 270:22731.

    Article  PubMed  CAS  Google Scholar 

  • Balboa, M.A., Firestein, B.L., Godson, C, Bekk, K.S., and Insel, P.A., 1994, Protein kinase Cα mediates phospholipase D activation by nucleotides and phorbol ester in Madin-Darby canine kidney cells. Stimulation of phospholipase D is independent of activation of polyphosphoinositide-specific phospholipase C and phospholipase A2, J. Biol. Chem. 269:10511.

    PubMed  CAS  Google Scholar 

  • Billah, M.M., and Anthes, J.C., 1990, The regulation and cellular functions of phosphatidylcholine hydrolysis, Biochem. J. 269:281.

    PubMed  CAS  Google Scholar 

  • Bocckino, S.B. and Exton, J.H., 1996, Handbook of Lipid Research, Plenum, New York.

    Google Scholar 

  • Bokoch, G.M., Bohl, B.P., and Chuang, T.-H., 1994, Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins, J. Biol. Chem. 269:31674.

    PubMed  CAS  Google Scholar 

  • Bourgoin, S. and Grinstein, S., 1992, Peroxides of vanadate induce activation of phospholipase D in HL-60 cells. Role of tyrosine phosphorylation, J. Biol. Chem. 267:11908.

    PubMed  CAS  Google Scholar 

  • Bourgoin, S., Harbour, D., Desmarais, Y., Takai, Y., and Beaulieu, A., 1995, Low molecular weight GTP-binding proteins in HL-60 granulocytes. Assessment of the role of ARF and of a 50-kDa cytosolic protein in phospholipase D activation, J. Biol. Chem. 270:3172.

    Article  PubMed  CAS  Google Scholar 

  • Bowman, E.P., Uhlinger, D.J., and Lambeth, J.D., 1993, Neutrophil phospholipase D is activated by a membrane-associated Rho family small molecular weight GTP-binding protein, J. Biol. Chem. 268:21509.

    PubMed  CAS  Google Scholar 

  • Briscoe, C.P., Martin, A., Cross, M., and Wakelam, M.J.O., 1995, The roles of multiple pathways in regulating bombesin-stimulated phospholipase D activity in Swiss 3T3 fibroblasts, Biochem. J. 306:115.

    PubMed  CAS  Google Scholar 

  • Brown, H.A., Gutowski, S., Moomaw, C.R., Slaughter, C, and Sternweis, P.C., 1993, ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity, Cell 75:1137.

    Article  PubMed  CAS  Google Scholar 

  • Brown, H.A., Gutowski, S., Kahn, R.A., and Sternweis, P.C., 1995, Partial purification and characterization of Arf-sensitive phospholipase D from porcine brain, J. Biol. Chem. 270: 14935.

    Article  PubMed  CAS  Google Scholar 

  • Cockcroft, S., Thomas, G.M.H., Fensome, A., Geny, B., Cunningham, E., Gout, I., Hiles, I., Totty, N.F., Truong, O., and Hsuan, J.J., 1994, Phospholipase D: A downstream effector of ARF in granulocytes, Science 263:523.

    Article  PubMed  CAS  Google Scholar 

  • Conricode, K.M., Brewer, K.A., and Exton, J.H., 1992, Activation of phospholipase D by protein kinase C. Evidence for a phosphorylation-independent mechanism, J. Biol. Chem. 267:7199.

    PubMed  CAS  Google Scholar 

  • Conricode, K.M., Smith, J.L., Burns, D.J., and Exton, J.H., 1994, Phospholipase D activation in fibroblast membranes by the α and ß isoforms of protein kinase C, FEBS Lett. 342:149.

    Article  PubMed  CAS  Google Scholar 

  • Coorssen, J.R., and Haslam, R.J., 1993, GTPγS and phorbol ester act synergistically to stimulate both Ca2+-independent secretion and phospholipase D activity in permeabilized human platelets. Inhibition by BAPTA and analogues, FEBS Lett. 316:170.

    Article  PubMed  CAS  Google Scholar 

  • Dinh, T.T., and Kennerly, D.A., 1991, Assessment of receptor-dependent activation of phosphatidylcholine hydrolysis by both phospholipase D and phospholipase C, Cell Regul. 2:299.

    PubMed  CAS  Google Scholar 

  • Donaldson, J.G., Finazzi, D., and Klausner, R.D., 1992, Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein, Nature 360:350.

    Article  PubMed  CAS  Google Scholar 

  • Dubyak, G.R., Schomisch, S.J., Kusner, D.J., and Xie, M., 1993, Phospholipase D activity in phagocytic leucocytes is synergistically regulated by G-protein-and tyrosine kinase-based mechanisms, Biochem. J. 292:121.

    PubMed  CAS  Google Scholar 

  • Eldar, H., Ben-Av, P., Schmidt, U.-S., Livneh, E., and Liscovitch, M., 1993, Up-regulation of phospholipase D activity induced by overexpression of protein kinase C-α Studies in intact swiss/3T3 cells and in detergent-solubilized membranes in vitro, J. Biol.Chem. 268:12560.

    PubMed  CAS  Google Scholar 

  • Exton, J.H., 1990, Signaling through phosphatidylcholine breakdown, J. Biol. Chem. 265:1.

    PubMed  CAS  Google Scholar 

  • Exton, J.H., 1994, Phosphatidylcholine breakdown and signal transduction, Biochim. Biophys. Acta 1212:26.

    Article  PubMed  CAS  Google Scholar 

  • Geny, B. and Cockcroft, S., 1992, Synergistic activation of phospholipase D by protein kinase C-and G-protein-mediated pathways in streptolysin O-permeabilized HL60 cells, Biochem. J. 284:531.

    PubMed  CAS  Google Scholar 

  • Geny, B., Fensome, A., and Cockcroft, S., 1993, Rat brain cytosol contains a factor which reconstitutes guanine-nucleotide-binding-protein-regulated phospholipase-D activation in HL60 cells previously permeabilized with streptolysin O, Eur. J. Biochem. 215:389.

    Article  PubMed  CAS  Google Scholar 

  • Halenda, S.P., and Rehm, A.G., 1990, Evidence for the calcium-dependent activation of phospholipase D in thrombin-stimulated human erythroleukemia cells, Biochem. J. 267:479.

    PubMed  CAS  Google Scholar 

  • Hammond, S.M., Altshuller, Y.M., Sung, T.-C, Rudge, S.A., Rose, S., Engebrecht, J.A., Morris, A.J., and Frohman, M.A., 1995, Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family, J. Biol. Chem. 270:29640.

    Article  PubMed  CAS  Google Scholar 

  • Helms, J.B., and Rothman, J.E., 1992, Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF, Nature 360:352.

    Article  PubMed  CAS  Google Scholar 

  • Houle, M.G., Kahn, R.A., Naccache, P.H., and Bourgoin, S., 1995, ADP-ribosylation factor translocation correlates with potentiation of GTPγS-stimulated phospholipase D activity in membrane fractions of HL-60 cells, J. Biol. Chem. 270:22795.

    Article  PubMed  CAS  Google Scholar 

  • Huang, R., Kucera, G.L., and Rittenhouse, S.E., 1991, Elevated cytosolic Ca2+ activates phospholipase D in human platelets, J. Biol. Chem. 266:1652.

    PubMed  CAS  Google Scholar 

  • Jiang, H., Lu, Z., Luo, J.-Q., Wolfman, A., and Foster, D.A., 1995a, Ras mediates the activation of phospholipase D by v-Src, J. Biol. Chem.270:6006.

    Article  PubMed  CAS  Google Scholar 

  • Jiang, H., Luo, J.-Q., Urano, T., Frankel, P., Lu, Z., Foster, D.A., and Feig, L.A., 1995b, Involvement of Ral GTPase in v-Src-induced phospholipase D activation, Nature 378:409.

    Article  PubMed  CAS  Google Scholar 

  • Kater, L.A., Goetzl, E.J., and Austen, K.F., 1976, Isolation of human eosinophil phospholipase D, J. Clin. Invest. 57:1173.

    Article  PubMed  CAS  Google Scholar 

  • Kessels, G.C.R., Roos, D., and Verhoeven, A.J., 1991, fMet-leu-phe-induced activation of phospholipase D in human neutrophils. Dependence on changes in cytosolic free Ca2+ concentration and relation with respiratory burst activation, J. Biol. Chem. 266:23152.

    PubMed  CAS  Google Scholar 

  • Khosravi-Far, R., Solski, P.A., Clark, G.J., Kinch, M.S., and Der, C.J., 1995, Activation of Racl, RhoA, and mitogen-activated protein kinases is required for Ras transformation, Mol. Cell. Biol. 15:6443.

    PubMed  CAS  Google Scholar 

  • Knaus, U.G., Morris, S., Dong, H.-J., Chernoff, J., and Bokoch, G.M., 1995, Regulation of human leukocyte p21-activated kinases through G protein-coupled receptors, Science 269:221.

    Article  PubMed  CAS  Google Scholar 

  • Kobayashi, M., and Kanfer, J.N., 1991, Solubilization and purification of rat tissue phospholipase D, Meth. Enzymol. 197:575.

    Article  PubMed  CAS  Google Scholar 

  • Kozma, R., Ahmed, S., Best, A., and Lim, L., 1995, The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts, Molec. Cell. Biol. 15:1942.

    PubMed  CAS  Google Scholar 

  • Ktistakis, N.T., Brown, H.A., Sternweis, P.C., and Roth, M.G., 1995, Phospholipase D is present on Golgi-enriched membranes and its activation by ADP-ribosylation factor is sensitive to brefeldin A, Proc. Natl. Acad. Sci. USA 92:4952.

    Article  PubMed  CAS  Google Scholar 

  • Kumada, T., Miyata, H., and Nozawa, Y., 1993, Involvement of tyrosine phosphorylation in IgE receptor-mediated phospholipase D activation in rat basophilic leukemia (RBL-2H3) cells, Biochem. Biophys. Res. Commun. 191:1363.

    Article  PubMed  CAS  Google Scholar 

  • Kumagai, N., Morii, N., Ishizaki, T., Watanabe, N., Fukisawa, K., Saito, Y., and Narumiya, S., 1995, Lysophosphatidic acid-induced activation of protein Ser/Thr kinases in cultured rat 3Y1 fibroblasts. Possible involvement in rho p21-mediated signalling, FEBS Lett. 366:11.

    Article  PubMed  CAS  Google Scholar 

  • Kuribara, H., Tago, K., Yokozeki, T., Sasaki, T., Takai, Y., Morii, N., Narumiya, S., Katada, T., and Kanaho, Y., 1995, Synergistic activation of rat brain phospholipase D by ADP-ribosylation factor and rhoA p21, and its inhibition by Clostridium botulinum C3 exoenzyme, J. Biol. Chem. 270:25667.

    Article  PubMed  CAS  Google Scholar 

  • Kusner, D.J., Schomisch, S.J., and Dubyak, G.R., 1993, ATP-induced potentiation of G-protein-dependent phospholipase D activity in a cell-free system from U937 promonocytic leukocytes, J. Biol. Chem. 268:19973.

    PubMed  CAS  Google Scholar 

  • Kwak, J.-Y., Lopez, I., Uhlinger, D.J., Ryu, S.Y., and Lambeth, J.D., 1995, RhoA and a cytosolic 50-kDa factor reconstitute GTPγS-dependent phospholipase D activity in human neutrophil subcellular fractions, J. Biol. Chem. 270:27093.

    Article  PubMed  CAS  Google Scholar 

  • Lambeth, J.D., Kwak, J.-Y., Bowman, E.P., Perry, D., Uhlinger, D.J., and Lopez, I., 1995, ADP-ribosylation factor functions synergistically with a 50-kDa cytosolic factor in cell-free activation of human neutrophil phospholipase D, J. Biol. Chem. 270:2431.

    Article  PubMed  CAS  Google Scholar 

  • Lee, Y.H., Kim, H.S., Pai, J.-K., Ryu, S.H., and Suh, P.-G., 1994, Activation of phospholipase D induced by platelet-derived growth factor is dependent upon the level of phospholipase C-γ1, J. Biol. Chem. 269:26842.

    PubMed  CAS  Google Scholar 

  • Leung, T., Manser, E., Tan, L., and Lim, L., 1995, A novel serine-threonine kinase binding the ras-related RhoA GTPase which translocates the kinase to peripheral membranes, J. Biol. Chem. 270:29051.

    Article  PubMed  CAS  Google Scholar 

  • Lin, P., and Gilfillan, A.M., 1992, The role of calcium and protein kinase C in the IgE-dependent activation of phosphatidylcholine-specific phospholipase D in a rat mast (RBL 2H3) cell line, Eur. J. Biochem. 207:163.

    Article  PubMed  CAS  Google Scholar 

  • Lin, P., Fung, W.-J.C., Li, S., Chen, T., Repetto, B., Huang, K.-S., and Gilfillan, A.M., 1994, Temporal regulation of the IgE-dependent 1,2-diacylglycerol production by tyrosine kinase activation in a rat (RBL2H3) mast-cell line, Biochem. J. 299:109.

    PubMed  CAS  Google Scholar 

  • Lopez, I., Burns, D.J., and Lambeth, J.D., 1995, Regulation of phospholipase D by protein kinase C in human neutrophils. Conventional isoforms of protein kinase C phosphorylate a phospholipase D-related component in the plasma membrane, J. Biol. Chem. 270:19465.

    Article  PubMed  CAS  Google Scholar 

  • Malcolm, K.C., Elliott, C.M., and Exton, J.H., 1996, Evidence for Rho-mediated agonist stimulation of phospholipase D in Rat1 fibroblasts. Effects of Clostridium botulinum C3 exoenzyme, J. Biol. Chem. (In press).

    Google Scholar 

  • Malcolm, K.C., Ross, A.H., Qiu, R.-G., Symons, M., and Exton, J.H., 1994, Activation of rat liver phospholipase D by the small GTP binding protein rhoA, J. Biol. Chem.269:25951.

    PubMed  CAS  Google Scholar 

  • Manser, E., Leung, T., Salihuddlin, H., Zhao, Z.-s., and Lim, L., 1994, A brain serine/threonine protein kinase activated by Cdc42 and Racl, Nature 367:40.

    Article  PubMed  CAS  Google Scholar 

  • Martin, G.A., Bollag, G., McCormick, F., and Abo, A., 1995, A novel serine kinase activated by racl/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20, EMBO J. 14:1970.

    PubMed  CAS  Google Scholar 

  • Martinson, E., Scheible, S., and Presek, P., 1994, Inhibition of phospholipase D of human platelets by protein tyrosine kinase inhibitors, Cell. Mol. Biol. 40:627.

    PubMed  CAS  Google Scholar 

  • Massenburg, D., Han, J.-S., Liyanage, M., Patton, W.A., Rhee, S.G., Moss, J., and Vaughan, M., 1994, Activation of rat brain phospholipase D by ADP-ribosylation factors 1, 5, and 6: Separation of ADP-ribosylation factor-dependent and oleate-dependent enzymes, Proc. Natl. Acad. Sci. USA 91:11718.

    Article  PubMed  CAS  Google Scholar 

  • Matuoka, L., Shibasaki, F., Shibata, M., and Takenawa, T., 1993, Ash/Grb-2, a SH2/SH3-containing protein, couples to signaling for mitogenesis and cytoskeletal reorganization by EGF and PDGF, EMBO J. 12:3467.

    PubMed  CAS  Google Scholar 

  • McGlade, J., Brunkhorst, B., Anderson, D., Mbamalu, G., Settleman, J., Dedhar, S., Rozakis-Adcock, M., Chen, L.B., and Pawson, T., 1993, The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion, EMBO J. 12:3073.

    PubMed  CAS  Google Scholar 

  • Nobes, C.D., and Hall, A., 1995, Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia, Cell 81:53.

    Article  PubMed  CAS  Google Scholar 

  • Nobes, C.D., Hawkins, P., Stephens, L., and Hall, A., 1995, Activation of the small GTP-binding proteins rho and rac by growth factor receptors, J. Cell Sci. 108:225.

    PubMed  CAS  Google Scholar 

  • Ohguchi, K., Banno, Y., Nakashima, S., and Nozawa, Y., 1995, Activation of membrane-bound phospholipase D by protein kinase C in HL60 cells: synergistic action of a small GTP-binding protein RhoA, Biochem. Biophys. Res. Commun. 211:306.

    Article  PubMed  CAS  Google Scholar 

  • Ohguchi, K., Banno, Y., Nakashima, S., and Nozawa, Y., 1996, Regulation of membrane-bound phospholipase D by protein kinase C in HL60 cells. Synergistic action of small GTP-binding protein RhoA, J. Biol. Chem. 271:4366.

    Article  PubMed  CAS  Google Scholar 

  • Okamura, S.-L., and Yamashita, S., 1994, Purification and characterization of phosphatidylcholine phospholipase D from pig lung, J. Biol.Chem. 269:31207.

    PubMed  CAS  Google Scholar 

  • Olson, M.F., Ashworth, A., and Hall, A., 1995, An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1, Science 269:1270.

    Article  PubMed  CAS  Google Scholar 

  • Olson, S.C., Bowman, E.P., and Lambeth, J.D., 1991, Phospholipase D activation in a cell-free system from human neutrophils by phorbol 12-myristate 13-acetate and guanosine 5’-0-(3-thiotriphosphate). Activation is calcium dependent and requires protein factors in both the plasma membrane and cytosol, J. Biol. Chem. 266:17236.

    PubMed  CAS  Google Scholar 

  • Pachter, J.A., Pai, J.-K., Mayer-Ezell, R., Pétrin, J.M., Dobek, E., and Bishop, W.R., 1992, Differential regulation of phosphoinositide and phosphatidylcholine hydrolysis by protein kinase C-βl overexpression. Effects on stimulation by α-thrombin, guanosine 5 ′-0-(thiotriphosphate), and calcium, J. Biol. Chem. 267:9826.

    PubMed  CAS  Google Scholar 

  • Pai, J.-K., Dobek, E.A., and Bishop, W.R., 1991, Endothelin-1 activates phospholipase D and thymidine incorporation in fibroblasts overexpressing protein kinase C, Cell Regul. 2: 897.

    PubMed  CAS  Google Scholar 

  • Paterson, H.F., Self, A.J., Garrett, M.D., Just, I., Aktories, K., and Hall, A., 1990, Microinjection of recombinant p21rho induces rapid changes in cell morphology, J. Cell Biol. Ill: 1001.

    Article  Google Scholar 

  • Prendergast, G.C., Khosravi-Far, R., Solski, P.A., Kurzawa, H., Lebowitz, P.F., and Der, C.J., 1995, Critical role of Rho in cell transformation by oncogenic Ras, Oncogene 10:2289.

    PubMed  CAS  Google Scholar 

  • Provost, J.J., Fudge, J., Israelit, S., Siddiqi, A.R., and Exton, J.H., 1996, Tissue specific distribution and subcellular distribution of phospholipase D in rat. Evidence for distinct RhoA-and ARF-regulated isozymes, Biochem. J. (submitted).

    Google Scholar 

  • Qian, Z., and Drewes, L.R., 1989, Muscarinic acetylcholine receptor regulates phosphatidylcholine phospholipase D in canine brain, J. Biol. Chem. 264:21720.

    PubMed  CAS  Google Scholar 

  • Qiu, R.-G., Chen, J., Korn, D., McCormick, F., and Symons, M., 1995, An essential role for Rac in Ras transformation, Nature 374:457.

    Article  PubMed  CAS  Google Scholar 

  • Qiu, R.-G., Chen, J., McCormick, F., and Symons, M., 1995, A role for Rho in Ras transformation, Proc. Natl. Acad. Sci. USA 92:11781.

    Article  PubMed  CAS  Google Scholar 

  • Randazzo, P.A., Yang, Y.C., Rulka, C, and Kahn, R.A., 1993, Activation of ADP-ribosylation factor by Golgi membranes. Evidence for a brefeldin A-and protease-sensitive activating factor on Golgi membranes, J. Biol.Chem. 268:9555.

    PubMed  CAS  Google Scholar 

  • Rankin, S., Morii, N., Narumiya, S., and Rozengurt, E., 1994, Botulinum C3 exoenzyme blocks the tyrosine phosphorylation of pl25FAK and paxillin induced by bombesin and endothelin, FEBS Lett. 354:315.

    Article  PubMed  CAS  Google Scholar 

  • Ridley, A.J., 1994, Membrane ruffling and signal transduction, BioEssays 5:321.

    Article  Google Scholar 

  • Ridley, A.J., and Hall, A., 1992, The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors, Cell 70:389.

    Article  PubMed  CAS  Google Scholar 

  • Ridley, A.J., Paterson, H.F., Johnston, C.L., Diekmann, D., and Hall, A., 1992, The small GTP-binding protein rac regulates growth factor-induced membrane ruffling, Cell 70:401.

    Article  PubMed  CAS  Google Scholar 

  • Rümenapp, U., Geiszt, M., Wahn, F., Schmidt, M., and Jakobs K.H., 1995, Evidence for ADP-ribosylation-factor-mediated activation of phospholipase D by m3 muscarinic acetylcholine receptor, Eur. J. Biochem. 234:240.

    Article  PubMed  Google Scholar 

  • Schmidt, M., Huwe, S.M., Fasselt, B., Homann, D., Rümenapp, U., Sandmann, J., and Jakobs, K.H., 1994, Mechanisms of phospholipase D stimulation by m3 muscarinic acetylcholine receptors. Evidence for involvement of tyrosine phosphorylation, Eur. J. Biochem. 225:667.

    Article  PubMed  CAS  Google Scholar 

  • Seckl, M.J., Morii, N., Narumiya, S., and Rozengurt, E., 1995, Guanosine 5′-3-O-(Thio)triphosphate stimulates tyrosine phosphorylation of pl25FAK and paxillin in permeabilized Swiss 3T3 cells. Role of p21rho, J. Biol.Chem. 270:6984.

    Article  PubMed  CAS  Google Scholar 

  • Siddiqi, A.R., Smith, J.L., Ross, A.H., Qiu, R.-G., Symons, M., and Exton, J.H., 1995, Regulation of phospholipase D in HL60 cells. Evidence for a cytosolic/phospholipase D, J. Biol. Chem. 270:8466.

    Article  PubMed  CAS  Google Scholar 

  • Singer, W.D., Brown, H.A., Bokoch, G.M., and Sternweis, P.C., 1995, Resolved phospholipase D activity is modulated by cytosolic factors other than Arf, J. Biol. Chem. 270:14944.

    Article  PubMed  CAS  Google Scholar 

  • Singer, W.D., Brown, H.A., Jiang, X., and Sternweis, P.C., 1996, Regulation of phospholipase D by protein kinase C is synergistic with ADP-ribosylation factor and independent of protein kinase activity, J. Biol. Chem. 271:4504.

    Article  PubMed  CAS  Google Scholar 

  • Song, J., Pfeffer, L.M., and Foster, D.A., 1991, v-Src increases diacylglycerol levels via a type D phospholipase-mediated hydrolysis of phosphatidylcholine, Molec. Cell. Biol. 11:4903.

    PubMed  CAS  Google Scholar 

  • Stewart, S.J., Cunningham, G.R., Strupp, J.A., House, F.S., Kelley, L.L., Henderson, G.S., Exton, J.H., and Bocckino, S.B., 1991, Activation of phospholipase D: a signaling system set in motion by perturbation of the T lymphocyte antigen receptor/CD3 complex, Cell Regul. 2:841.

    PubMed  CAS  Google Scholar 

  • Takai, Y., Sasaki, T., Tanaka, K., and Nakanishi, H., 1995, Rho as a regulator of the cytoskeleton, Trends Biochem. Sci. 20:227.

    Article  PubMed  CAS  Google Scholar 

  • Taki, T., and Kanfer, J.N., 1979, Partial purification and properties of a rat brain phospholipase D, J. Biol. Chem. 254:9761.

    PubMed  CAS  Google Scholar 

  • Uings, I.J., Thompson, N.T., Randall, R.W., Spacey, G.D., Bonser, R.W., Hudson, A.T., and Garland, L.G., 1992, Tyrosine phosphorylation is involved in receptor coupling to phospholipase D but not phospholipase C in the human neutrophil, Biochem. J. 281:597.

    PubMed  CAS  Google Scholar 

  • Wang, P., Anthes, J.C., Siegel, M.I., Egan, R.W., and Billah, M.M., 1991, Existence of a cytosolic phospholipase D. Identification and comparison with membrane-bound enzyme, J. Biol. Chem.266:14877.

    PubMed  CAS  Google Scholar 

  • Ward, D.T., Ohanian, J., Heagerty, A.M., and Ohanian, V., 1995, Phospholipase D-induced phosphatidate production in intact small arteries during noradrenaline stimulation: involvement of both G-protein and tyrosine-phosphorylation-1inked pathways, Biochem. J. 307:451.

    PubMed  CAS  Google Scholar 

  • Weiss, A., 1993, T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases, Cell 73:209.

    Article  PubMed  CAS  Google Scholar 

  • Wilkes, L.C., Patel, V., Purkiss, J.R., and Boarder, M.R., 1993, Endothelin-1 stimulated phospholipase D in A10 vascular smooth muscle derived cells is dependent on tyrosine kinase, FEBS Lett. 322:147.

    Article  PubMed  CAS  Google Scholar 

  • Wu, H., James-Kracke, M.R., and Halenda, S.P., 1992, Direct relationship between intracellular calcium mobilization and phospholipase D activation in prostaglandin E-stimulated human erythroleukemia cells, Biochem. 31:3370.

    Article  CAS  Google Scholar 

  • Yeo, E.-J., Kazlauskas, A., and Exton, J.H., 1994, Activation of phospholipase C-α is necessary for stimulation of phospholipase D by platelet-derived growth factor, J. Biol. Chem. 269:27823.

    PubMed  CAS  Google Scholar 

  • Zhang, G.-F., Patton, W.A., Lee, F.-J.S., Liyanage, M., Han, J.-S., Rhee, S.G., Moss, J., and Vaughan, M., 1995, Different ARF domains are required for the activation of cholera toxin and phospholipase D, J.Biol. Chem. 270:21.

    Article  PubMed  CAS  Google Scholar 

  • Zhang, S., Han, J., Sells, M.A., Chernoff, J., Knaus, U.G., Olevitch, R.J., and Bokoch, G.M., 1995, Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1, J. Biol.Chem. 270:23934.

    Article  PubMed  CAS  Google Scholar 

  • Zubiaur, M., Sancho, J., Terhorst, C., and Faller, D.V., 1995, A Small GTP-binding protein, Rho, associates with the platelet-derived growth factor type-ß receptor upon ligand binding, J. Biol. Chem. 270:17221.

    Article  PubMed  CAS  Google Scholar 

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  1. Howard Hughes Medical Institute and Department of Molecular Physiology and Biophysics and Pharmacology, Vanderbilt University School of Medicine Nashville, TN, USA

    John H. Exton

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  1. The George Washington University Medical Center, Washington, D.C., USA

    Jack Y. Vanderhoek

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Exton, J.H. (1996). Phospholipase D. In: Vanderhoek, J.Y. (eds) Frontiers in Bioactive Lipids. GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5875-0_35

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  • DOI: https://doi.org/10.1007/978-1-4615-5875-0_35

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7694-1

  • Online ISBN: 978-1-4615-5875-0

  • eBook Packages: Springer Book Archive

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