Abstract
Platelet-activating factor (PAF) is synthesized by either de novo or remodeling enzymes (Snyder, 1995a,b). The remodeling of a preexisting membrane phospholipid, 1-alkyl-2-acyl-sn-glycero-3-phosphocholine (alkylacyl-GPC), to form PAF can occur via the direct action of a phospholipase A2 (PLA2) or via a stepwise reaction sequence catalyzed by CoA-independent (CoA-ind) or CoA-dependent (CoA-dep) transacylases. Once PAF is synthesized, its acetate moiety can be transferred to other lysophospholipids and fatty alcohols as well as to sphingosine by a CoA-independent transacetylase. The C2-ceramides that are produced are of special interest in view of their known biological activities.
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References
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Snyder, F., Lee, TC., Blank, M.L., Shinozaki, K., Ou, MC., Fitzgerald, V. (1996). Biosynthesis of Platelet Activating Factor and Related Acetylated Lipids. In: Vanderhoek, J.Y. (eds) Frontiers in Bioactive Lipids. GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5875-0_31
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DOI: https://doi.org/10.1007/978-1-4615-5875-0_31
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