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The Role of Long Chain Acyl-CoA Esters in the Regulation of Gene Expression and Metabolism in Escherichia Coli

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Frontiers in Bioactive Lipids

Abstract

The pathways of lipid synthesis and degradation are co-ordinately regulated in most cells at the level of transcription. A number of studies have been directed at elucidating a role for acyl-CoA compounds in the regulation of the activity of lipid-responsive transcription factors24,25,28,32. However, there has been only indirect evidence that acyl-CoA compounds regulate eucaryotic gene activity by interaction with transcription factors 1,7,8,15,36. Escherichia coli FadR is the only transcription factor for which there is substantial and convincing evidence that direct binding of LCACoA to the protein prevents DNA binding, transcription activation or repression 11,12,17. Among the genes directly regulated by FadR are those encoding a specific membrane associated fatty acid transport protein (FadL), acyl-CoA synthetase, all the enzymes required for the ß-oxidation of fatty acids, two enzymes essential for unsaturated fatty acid biosynthesis and a protein of undetermined function which is expressed during a number of stress reponses 2,14. In this article we review our current understanding of FadR-dependent gene regulation and regulation of FadR by long chain acyl-CoA.

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Authors and Affiliations

  1. Department of Biochemistry, University of Tennessee, Memphis, TN, 38163, USA

    Concetta C. DiRusso

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  1. Concetta C. DiRusso
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  1. The George Washington University Medical Center, Washington, D.C., USA

    Jack Y. Vanderhoek

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DiRusso, C.C. (1996). The Role of Long Chain Acyl-CoA Esters in the Regulation of Gene Expression and Metabolism in Escherichia Coli . In: Vanderhoek, J.Y. (eds) Frontiers in Bioactive Lipids. GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5875-0_3

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  • DOI: https://doi.org/10.1007/978-1-4615-5875-0_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7694-1

  • Online ISBN: 978-1-4615-5875-0

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