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The Role of Ceramide in the Cellular Stress Response

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Frontiers in Bioactive Lipids

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Abstract

The cellular response to stressful environmental conditions is complex and only partially understood. Cells can be stressed by nutritional starvation, infection, physical or chemical conditions (e.g. heat, extreme pH), genotoxic drugs, or other conditions. During evolution, various stress responses were preserved to allow cells or organisms to withstand different forms of stress by organizing the repair of proteins and DNA that had been damaged by the particular stressful event. The specific stress response is probably determined and regulated by the nature of the insulting condition. Despite the importance of these processes, our knowledge remains limited1-3.

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Authors and Affiliations

  1. Department of Pediatrics, Duke University Medical Center, Durham, NC, 27710, USA

    Ghassan S. Dbaibo

  2. Department of Medicine, Duke University Medical Center, Durham, NC, 27710, USA

    Lina M. Obeid & Yusuf A. Hannun

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  1. Ghassan S. Dbaibo
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  2. Lina M. Obeid
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  1. The George Washington University Medical Center, Washington, D.C., USA

    Jack Y. Vanderhoek

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Dbaibo, G.S., Obeid, L.M., Hannun, Y.A. (1996). The Role of Ceramide in the Cellular Stress Response. In: Vanderhoek, J.Y. (eds) Frontiers in Bioactive Lipids. GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5875-0_25

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