Abstract
The lipoxygenases are a family of enzymes that stereospecifically insert molecular oxygen onto defined positions of arachidonic acid giving rise to various eicosanoids including leukotrienes, lipoxins and hydro(pero)xy-eicosatetraenoic (H(P)ETE) acids (1). There are at least four lipoxygenase (LO) forms in mice, each encoded by a separate gene. The precise roles of the various metabolites are poorly understood in many cases. In our laboratory, we have carried out the cloning and inactivation of three murine LO genes (5-LO, leukocyte-type 12-LO and platelet-type 12-LO) to examine potential biological functions of eicosanoids.
Keywords
- Arachidonic Acid
- Peritoneal Macrophage
- Deficient Mouse
- Allergic Airway Inflammation
- Calcium Ionophore A23187
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© 1996 Springer Science+Business Media New York
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Funk, C.D., Sun, D. (1996). Manipulations of the Arachidonic Acid Cascade with Lipoxygenase Gene-Inactivated Mice. In: Vanderhoek, J.Y. (eds) Frontiers in Bioactive Lipids. GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5875-0_18
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DOI: https://doi.org/10.1007/978-1-4615-5875-0_18
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-7694-1
Online ISBN: 978-1-4615-5875-0
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