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The cyclin C/Cdk8 kinase

  • Chapter
Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

Cyclin C was originally identified in a genetic screen for metazoan cDNAs that complement a triple knock-out of the CLN genes, involved in G1/S progression in S. cerevisiae. Unlike cyclin Ds and cyclin E, also identified in this screen, cyclin C has not been found to have a cell-cycle role in metazoa. Identified as the catalytic partner of cyclin C, Cdk8 is a novel protein-kinase of the Cdk family structurally related to the yeast Srb10 kinase. Cyclin C, Cdk8 and RNA polymerase II are found in a large multi-protein complex that shows structural as well as functional homologies with the yeast polymerase II holoenzyme. These observations and the sequence similarity to the kinase/cyclin pair Srb10/Srb11 in S. cerevisiae, suggest that cyclin C and Cdk8 control RNA polymerase II function.

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Author information

Authors and Affiliations

  1. URA 671 CNRS, BP28, 06230, Villefranche-sur-mer, France

    Vincent Leclerc & Pierre Léopold

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  1. Vincent Leclerc
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  2. Pierre Léopold
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Editors and Affiliations

  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer , Silvana Guidet  & Lee Vogel ,  & 

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Leclerc, V., Léopold, P. (1996). The cyclin C/Cdk8 kinase. In: Meijer, L., Guidet, S., Vogel, L. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5873-6_19

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  • DOI: https://doi.org/10.1007/978-1-4615-5873-6_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7693-4

  • Online ISBN: 978-1-4615-5873-6

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