Abstract
Multiple System Organ Failure develops in 15% of surgical intensive care unit patients despite being adequately resuscitated by conventional criteria. Of these, greater than 50% will eventually die1. Some current theories implicate the persistence of inadequate gut oxygenation as the principle inciting event2,3. It is proposed that gut hypoxia compromises both mucosal barrier integrity and transmural oxidative bacterial killing. The net effect is an increased rate of bacterial translocation, which if unchecked can rapidly progress to sepsis and death. The early detection of gut hypoxia offers an opportunity to intervene and possibly prevent this scenario.
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© 1997 Springer Science+Business Media New York
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Suski, M.D., Zabel, D., Levin, V., Scheuenstuhl, H., Hunt, T.K. (1997). Effect of Hypoxic Hypoxia on Transmural Gut and Subcutaneous Tissue Oxygen Tension. In: Nemoto, E.M., et al. Oxygen Transport to Tissue XVIII. Advances in Experimental Medicine and Biology, vol 411. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5865-1_39
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DOI: https://doi.org/10.1007/978-1-4615-5865-1_39
Publisher Name: Springer, Boston, MA
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