Abstract
We started investigations on intratumoral oxygen tension after irradiations with reactor fission neutrons using the Eppendorf-pO 2 Histograph R. Isotransplanted AT17-mammary carcinomas on C3H-mice and osteosarcomas OTS-64 on balb C-mice received 2 or 6 Gy neutrons single dose. Before and at certain points of time after treatment the pO2 values were evaluated.
Some tumors with initially low median pO2 values showed a short-lasting increase between 2 and 24 h after irradiation. In those tumors with relatively high pretherapeutic pO2 values the pO2 decreased to the range of hypoxia. A third group of tumors showed no marked changes after irradiation. No tumor stopped growth during the observation period.
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Weissfloch, L., Auberger, T., Senekowitsch-Schmidtke, R., Wagner, F.M., Tempel, K., Molls, M. (1997). Oxygen Tensions in Rodent Tumors after Irradiation with Neutrons. In: Nemoto, E.M., et al. Oxygen Transport to Tissue XVIII. Advances in Experimental Medicine and Biology, vol 411. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5865-1_30
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DOI: https://doi.org/10.1007/978-1-4615-5865-1_30
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