Abstract
A major contributing factor in the failure of solid tumors to be locally controlled by radiation therapy (RT) is the relative radiation resistance of hypoxic cells of tumors compared to well-oxygenated cells. Recently clinical studies have established the presence of hypoxic regions in human tumors (1,2). Further studies confirmed that relatively high tissue pO2 in human tumors correlated with positive outcomes of radiation therapy and that poor outcomes were associated with tumors with low pO2 (3–6). As a result of available studies, the conclusion has been drawn that the effective level of oxygenation in individuals could not be predicted based on tumor type, histology, staging, or even size, but had to be measured (7). With the development of methods to measure the pO2 in tumors (8), it now seems feasible to determine if this parameter, which can be of crucial importance in radiation therapy, can be used to improve treatment by permitting individualized optimization of therapy on the basis of the pO2 in the tumor.
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O’Hara, J.A., Goda, F., Dunn, J.F., Swartz, H.M. (1997). Potential for EPR Oximetry to Guide Treatment Planning for Tumors. In: Nemoto, E.M., et al. Oxygen Transport to Tissue XVIII. Advances in Experimental Medicine and Biology, vol 411. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5865-1_28
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