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Can NMR Diffusion-Weighted Imaging Provide Quantitative Information on Tumor Interstital pO2?

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Book cover Oxygen Transport to Tissue XVIII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 411))

Abstract

Oxygenation (pO2) is a major variable in many types of cancer treatment. This includes radiation therapy1–6, photodynamic therapy7–9 and certain chemotherapeutic agents10–17. The pO2 level can affect the response of tumors to therapy, especially in the critical range below 10 mmHg, where increasing hypoxia results in increased resistance to radiotherapy18. If it were possible to measure pO2 in tumors, then it might be possible to optimize the type and timing of treatment.

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Author information

Authors and Affiliations

  1. NMR, Department of Diagnostic Radiology, Dartmouth Hitchcock Medical Center, HB 7786, Hanover, 03755, New Hampshire, USA

    J. F. Dunn & S. Ding

  2. EPR Research Centers, Department of Diagnostic Radiology, Dartmouth Hitchcock Medical Center, HB 7786, Hanover, 03755, New Hampshire, USA

    K. J. Liu, F. Goda & H. M. Swartz

  3. Department of Radiation Oncology, Dartmouth Hitchcock Medical Center, HB 7786, Hanover, 03755, New Hampshire, USA

    J. A. O’Hara & E. Rhodes

Authors
  1. J. F. Dunn
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  2. S. Ding
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  3. J. A. O’Hara
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  4. K. J. Liu
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  5. E. Rhodes
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  6. F. Goda
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  7. H. M. Swartz
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Editor information

Editors and Affiliations

  1. University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Edwin M. Nemoto

  2. Case Western Reserve University, Cleveland, Ohio, USA

    Joseph C. LaManna

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© 1997 Springer Science+Business Media New York

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Dunn, J.F. et al. (1997). Can NMR Diffusion-Weighted Imaging Provide Quantitative Information on Tumor Interstital pO2?. In: Nemoto, E.M., et al. Oxygen Transport to Tissue XVIII. Advances in Experimental Medicine and Biology, vol 411. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5865-1_25

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  • DOI: https://doi.org/10.1007/978-1-4615-5865-1_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7689-7

  • Online ISBN: 978-1-4615-5865-1

  • eBook Packages: Springer Book Archive

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