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Perfusion MRI Assessment of Cerebral Blood Flow and CO2 Reactivity after Controlled Cortical Impact in Rats

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Oxygen Transport to Tissue XVIII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 411))

Abstract

Contemporary animal models of traumatic brain injury (TBI)1,2,3 have provided insight into the mechanisms of brain injury by modeling features such as diffuse axonal injury and contusion. These models have also facilitated the study of the cellular and molecular mechanisms of secondary injury3,4,5 and have contributed to the development of clinical trials6.

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References

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  6. Muizelaar JP, Marmarou A, Young HF, Choi SC, Wolf A, Schneider RL, Kontos HA: Improving The Outcome Of Severe Head Injury With The Oxygen Radical Scavenger Polyethylene Glycol-Conjugated Superoxide Dismutase: A Phase II Trial. J Neurosurg 78(3):375–382, 1993

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  7. Williams DS, Detre JA, Leigh JS, Koretsky AP: Magnetic Resonance Imaging of Perfusion Using Spin Inversion of Arterial Water. Proc Natl Acad Sci USA 89:212–216, 1992

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Authors and Affiliations

  1. Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennsylvania, 15260, USA

    Michael L. Forbes, Joanne K. Schiding, Steven T. DeKosky, Donald W. Marion & Patrick M. Kochanek

  2. The University of Pittsburgh Brain Trauma Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, 15260, USA

    Steven T. DeKosky, Donald W. Marion & Patrick M. Kochanek

  3. Departments of Anesthesiology/Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, 15260, USA

    Patrick M. Kochanek

  4. Departments of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, 15260, USA

    Steven T. DeKosky

  5. Departments of Neurosurgery, University of Pittsburgh, Pittsburgh, Pennsylvania, 15260, USA

    Donald W. Marion

  6. The Pittsburgh NMR Center for Biomedical Research, Carnegie Mellon University, Pittsburgh, Pennsylvania, 15213, USA

    Kristy S. Hendrich, Donald S. Williams & Chien Ho

  7. Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, 15213, USA

    Chien Ho

Authors
  1. Michael L. Forbes
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  2. Kristy S. Hendrich
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  3. Joanne K. Schiding
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  4. Donald S. Williams
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  5. Chien Ho
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  6. Steven T. DeKosky
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  7. Donald W. Marion
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  8. Patrick M. Kochanek
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Editor information

Editors and Affiliations

  1. University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Edwin M. Nemoto

  2. Case Western Reserve University, Cleveland, Ohio, USA

    Joseph C. LaManna

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© 1997 Springer Science+Business Media New York

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Forbes, M.L. et al. (1997). Perfusion MRI Assessment of Cerebral Blood Flow and CO2 Reactivity after Controlled Cortical Impact in Rats. In: Nemoto, E.M., et al. Oxygen Transport to Tissue XVIII. Advances in Experimental Medicine and Biology, vol 411. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5865-1_2

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  • DOI: https://doi.org/10.1007/978-1-4615-5865-1_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7689-7

  • Online ISBN: 978-1-4615-5865-1

  • eBook Packages: Springer Book Archive

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