Abstract
This study determined the relationships of metabolic acidosis, cortical oxygen pressure, and striatal extracellular dopamine in the brain of newborn piglets. After a baseline period of 120 minutes, a 0.6 N HCl solution was infused intravenously to decrease the blood pH to about 7.0–7.05. The metabolic acidosis was then corrected by injecting sodium bicarbonate and measurements were continued for one hour. The results show that decreased blood pH to about 7.2–7.15 does not cause a statistically significant change in mean blood pressure, cortical oxygen pressure or striatal extracellular dopamine. Further decrease in pH caused significant decrease in both blood pressure and cortical oxygen pressure. By the end of the period of acidosis the cortical oxygen pressure decreased from the control value of 43 ± 4 Torr to 22 ± 8 Torr. Changes in the extracellular level of striatal dopamine were parallel to changes in cortical oxygen pressure. The extracellular dopamine increased to 1270 % of the control on the end of HCl injection. Infusion of bicarbonate to correct the acidosis resulted in an increase of cortical oxygen and progressive decline of dopamine in the extracellular medium. It is suggested that the level of extracellular dopamine in the striatum of newborn piglets was not directly affected by decrease in pH but was dependent on changes in tissue oxygen pressure during metabolic acidosis.
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References
Bersin R.M., Chatterjee K., and Arieff A.I. (1989) Metabolic and hemodynamic consequences of sodium bicarbonate administration in patients with heart disease. Am. J. Med. 87, 7–14.
Comline R.S., and Silver M. (1972) The composition of foetal and maternal blood during parturition in the ewe. J. Physiol. 222, 233–256.
Drewes L.R., and Gilboe D.G. (1973) Glycolysis and the permeation of glucose and lactate in the isolated perfused dog brain during anoxia and postanoxia recovery. J. Biol. Chem. 218, 2489–2496.
Fanconi S., Burger R., Ghelfi D., Uehlinger J., and Arbenz U. (1993) Hemodynamic effects of sodium bicarbonate in critiacally ill neonates. Int. Care Med. 19, 65–69.
Huang C., Lajevardi N., Tammela O., Pastuszko A., Delivoria-Papadopoulos M., and Wilson D.F. (1993) Relationship of extracellular dopamine in striatum of newborn piglets to cortical oxygen pressure. Neuroch. Res. 19, 649–655.
Iberti T.J., Kelly K.M., Gentil D.R., Rosen M., Katz D.P., Premus G., and Benjamin M. (1988) Effects of sodium bicarbonate in canine hemorrhagic shock. Crit. Care Med. 16, 779–782.
Kucera R.R., Shapiro J.I., Whalen M.A., Kindig N.B., Filley G.F., and Chan L. (1989) Brain pH effects of Na-HCO3 and Carbicarb in lactic acidosis. Crit. Care Med. 17, 1320–1323.
Makisalo H.J., Soini H.O., Nordin A.J., and Hoeckersted K.A.V. (1989) Effects of bicarbonate therapy on tissue oxygenation during resuscitation of hemorrhagic shock. Crit. Care Med. 17, 1170–1174.
Pastuszko A. (1994) Metabolic response of dopaminergic system during hypoxia-ischemia and reoxygenation in the immature brain. Biochem. Med. Metab. Biol. 51, 1–15
Pastuszko A., Lajevardi N., Chen J., Tammela O., Wilson D.F., and Delivoria-Papadopoulos M. (1993) Effects of graded levels of tissue oxygen pressure on dopamine metabolism in the striatum of newborn piglets. J. Neurochem. 60, 161–166.
Sessler D., Mills P., Gregory G., Litt L., and James T. (1987) Effects of bicarbonate on arterial and brain intracellular pH in neonatal rabbits recovering from hypoxic lactic acidosis. J. Pediatr. 111, 817–823.
Shapiro J.I., Whalen M.A., Kucera R.R., Kindig N.B., Filley G.F., and Chan L. (1989) Brain pH responses to sodium bicarbonate and carbicarb during systemic acidosis. Am. J. Physiol. 256, H1316–H1321.
Siesjo B.K. (1985) Acid-base homeostasis in the brain: Physiology, chemistry and neurochemical pathology. Progress in Brain Res. 63, 121–154.
Siesjo B.K. (1988) Acidosis and ischemic brain damage. Neurochem. Patholog. 9, 31–88.
Siesjo B.K., Katsura K-I., Mellergard P., Ekholm A., Lundgren J., and Smith M-L. (1993) Acidosis-related brain damage. Progress in Brain Res. 96, 23–48.
Siesjo B.K., and Zwetnow N. (1970) The effect of hypovol hypotension on extra and intracellular acid-base parameters and energy metabolites in the rat brain. Acta Physiol. Scand. 79, 114–124.
Vannucci R.C., and Duffy T.E. (1974) Influence of birth on carbohydrate and energy metabolism in rat brain. Am. Physiol. 226, 933–940.
Wagerle C. L., Kumar P.K., Belik J., and Delivoria-Papadopoulos M. (1988) Blood-brain barrier to hydrogen ion during acute metabolic acidosis in piglets. J. Appl. Physiol. 65, 776–781.
Walter J.H. (1992) Metabolic acidosis in newborn infants. Arch. Dis. Child 67, 767–769.
Wheeler A.S., Sadri S., Gutsche B.B., Devore J.S., David-Mian Z., and Latisevsky H. (1979) Intracraneal hemorrhage following intravenous administration of sodium bicarbonate or saline solution in the newborn lamb asphyxiated in utero. Anaesth. 51, 517–521.
Wilson D.F., Pastuszko A., DiGiacomo J.E., Pawlowski M., Schneiderman R., and Delivoria-Papadopoulos M. (1991) Effect of hyperventilation on oxygenation of the brain cortex of newborn piglets. J. Appl. Physiol. 70, 2691–2696.
Yashon D., Wagner C.F., Demian Y.K., and White R. (1970) Cerebral lactate accumulation and glucose exhaust during circulatory arrest. Pro. Soc. Exp. Biol. Med. 133, 728–730.
Yonetani M., Huang C., Lajevardi N., Pastuszko A., Delivoria-Papadopoulos M., and Wilson D.F (1994) Effect of hemorrhagic hypotension on extracellular level of dopamine, cortical oxygen pressure and blood flow in brain of newborn piglets. Neurosci. Lett. 180, 247–252.
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Tammela, O., Song, D., Olano, M., Delivoria-Papadopoulos, M., Wilson, D.F., Pastuszko, A. (1997). Response of Cortical Oxygen and Striatal Extracellular Dopamine to Metabolic Acidosis in Newborn Piglets. In: Nemoto, E.M., et al. Oxygen Transport to Tissue XVIII. Advances in Experimental Medicine and Biology, vol 411. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5865-1_13
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DOI: https://doi.org/10.1007/978-1-4615-5865-1_13
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