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Cytokine and Drug Modulation of TNFα in Mast Cells

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New Horizons in Allergy Immunotherapy

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 409))

Abstract

Mast cells (MC) are critical effector cells in allergic reactions, but also have the potential to regulate immune responses through the cytokines they produce (Table 1). These MC-derived multifunctional mediators (first mediator pool) recruit and activate other effector cells such as neutrophils, eosinophils and monocytes/macrophages, as well as MC themselves to produce a broader spectrum of mediators in large amounts (second mediator pool) to amplify the response (Figure 1). Because of the limitation of space, this brief review focuses on the production and regulation of the first mediator pool in MC.

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References

  1. Walsh LJ, Trinchieri G, Waldorf HA, Whitaker D and Murphy GF. Proc. Natl. Acad. Sci. USA. 1991; 88:4220.

    Article  PubMed  CAS  Google Scholar 

  2. Benyon RC, Bissonnette EY, and Befus AD. J. Immunol 1991; 147:2253.

    PubMed  CAS  Google Scholar 

  3. Bradding P, Feather IH, Bardin PG, Heusser CH, Holgate ST and Howarth PH. J. Immunol. 1993; 151:3853.

    PubMed  CAS  Google Scholar 

  4. Bradding P, Roberts JA, Britten KM, Montefort S, Djukanovic R, Mueller R, Heusser CH, Howarth PH and Holgate ST. Am. J. Respir. Cell Mol. Biol 1994; 10:471.

    PubMed  CAS  Google Scholar 

  5. Grabbe J, Welker P, Moller A, Dippel E, Ashman LK and Czarnetzki BM. J. Invest. Dermatol. 1994; 103:504.

    Article  PubMed  CAS  Google Scholar 

  6. Sillaber C, Bevec D, Butterfield JH, Heppner C, Valenta R, Scheiner O, Kraft D, Lechner K, Bettelheim P and Valent P. Exp. Hematol 1993; 21:1271.

    PubMed  CAS  Google Scholar 

  7. Young JD, Liu CC, Butler G, Cohn ZA and Galli SJ. Proc. Natl. Acad. Sci. USA. 1987; 84:9175.

    Article  PubMed  CAS  Google Scholar 

  8. Gordon JR and Galli SJ. Nature 1990; 346:274.

    Article  PubMed  CAS  Google Scholar 

  9. Bissonnette EY and Befus AD. J Immunol. 1990; 145:3385.

    PubMed  CAS  Google Scholar 

  10. Ansel JC, Brown JR, Payan DG and Brown MA. J. Immunol. 1993; 150:4478.

    PubMed  CAS  Google Scholar 

  11. Richards AL, Okuno T, Takagaki Y and Djeu JY J. Immunol. 1988; 141:3061.

    PubMed  CAS  Google Scholar 

  12. Baumgartner R, Yamada K, Deramo V Aand Beaven MA. J. Immunol. 1994; 153:2609.

    PubMed  CAS  Google Scholar 

  13. Zhang Y, Ramos BF and Jakschik B. Science 1992; 258:1957.

    Article  PubMed  CAS  Google Scholar 

  14. Leal-Berumen I, Conlon P and Marshall JS. J. Immunol. 1994; 152:5468.

    PubMed  CAS  Google Scholar 

  15. Meade R, Neddermann KM, Greenfield RS, Braslawsky G and Bursuker I. J. Leuk. Biol. 1993; 54:523.

    CAS  Google Scholar 

  16. Chung SW, Wong PMC, Shen-Ong G, Ruscetti S, Ishizaka T and Eaves CJ. Blood 1986; 68:1074.

    PubMed  CAS  Google Scholar 

  17. Nishikomori R, Kawai M, Jung EY, Tai G, Miyajima A, Arai N, Mayumi M and Heike T. J. Immuno. 1995; 154:694.

    CAS  Google Scholar 

  18. Hu ZQ, Yamazaki T, Cai Z, Yoshida T and Shimamura T. Immunology 1994; 82:482.

    PubMed  CAS  Google Scholar 

  19. Pennington DW, Lopez AR, Thomas PS, Peck C and Gold WM. J. Clin. Invest. 1992; 90:35.

    Article  PubMed  CAS  Google Scholar 

  20. Gordon JR and Galli SJ. J. Exp. Med. 1994; 180:2027.

    Article  PubMed  CAS  Google Scholar 

  21. Leon A, A. Buriani A, Dal Toso R, Fabris M, Romanello S, Aloe L and Lev-Montalcini R. Proc. Natl. Acad. Sci. USA 1994; 91:3739.

    Google Scholar 

  22. Horigome K, Bullock ED and Johnson EM Jr. J. Biol. Chem. 1994; 269:2695.

    PubMed  CAS  Google Scholar 

  23. Horigome K, Pryor JC, Bullock ED and Johnson EM Jr. J. Biol. Chem. 1993; 268:14881.

    PubMed  CAS  Google Scholar 

  24. Burd PR, Rogers HW, Gordon JR, Martin CA, Jayaraman S, Wilson SD, Dvorak AM, Galli SJ and Dorf ME. J. Exp. Med. 1989; 170:245.

    Article  PubMed  CAS  Google Scholar 

  25. Oh CK and Metcalfe DD. J. Immunol. 1994; 153:325.

    PubMed  CAS  Google Scholar 

  26. Selvan RS, Butterfield JH and Krangel MS. J. Biol. Chem. 1994; 269:13893.

    PubMed  CAS  Google Scholar 

  27. Alam R, Kumar D, Anderson-Walters D and Forsythe PA. J. Immunol. 1994; 152:1298.

    PubMed  CAS  Google Scholar 

  28. Taub D, Dastych J, Inamura N, Upton J, Kelvin D, Metcalfe D and Oppenheim J. J. Immunol. 1995; 154:2393.

    PubMed  CAS  Google Scholar 

  29. Mattoli S, Ackerman V, Vittori E and Marini M. Biochem. Biophy. Res. Commun. 1995; 209:316.

    Article  CAS  Google Scholar 

  30. Marshall JS, Gauldie J, Nielsen L and Bienenstock J. Eur. J. Immunol. 1993; 23:2116.

    Article  PubMed  CAS  Google Scholar 

  31. Renauld JC, Kermouni A, Vink A, Louahed J and Van Snick J. J. Leuk. Biol. 1995; 57:353.

    CAS  Google Scholar 

  32. Plaut M, Pierce JH, Watson CJ, Hanley-Hyde J, Nordan RP and Paul WE. Nature 1989; 339:64.

    Article  PubMed  CAS  Google Scholar 

  33. Buckley MG, Williams CMM, Thompson J, Pryor P, Ray K, Butterfield JH and Coleman JW. Immunology 1995; 84:410.

    PubMed  CAS  Google Scholar 

  34. Smith TJ, Ducharme LA and Weis JH. Eur. J. Immunol. 1994; 24:822.

    Article  PubMed  CAS  Google Scholar 

  35. Moller A, Lippert U, Lessmann D, Kolde G, Hamann K, Welker P, Schadendorf D, Rosenbach T, Luger T and B.M. Czarnetzki BM. J. Immunol. 1993; 151:3261.

    PubMed  CAS  Google Scholar 

  36. Zhang Y, Ramos BF, Jakschik B, Baganoff MP, Deppeler CL, Meyer DM, Widomski DL, Fretland DL and Bolanowski MA. Inflammation 1995; 19:119.

    Article  PubMed  CAS  Google Scholar 

  37. Szczepek A and Befus AD. Clin. Immunol. Immunopathol. 1995;76:S 115(Abstr).

    Google Scholar 

  38. Moore KW, Vieira P, Fiorentino DF, Troustine ML, Khan TA and Mosmann TR. Science 1990; 248:1230.

    Article  PubMed  CAS  Google Scholar 

  39. Burd PR, Thompson WC, Max EE and Mills FC. J. Exp. Med. 1995; 181:1373.

    Article  PubMed  CAS  Google Scholar 

  40. Coleman JW, Holliday MR, Kimber I, Zsebo KM and Galli SJ. J. Immunol. 1993; 150:556.

    PubMed  CAS  Google Scholar 

  41. Bissonnette EY and Befus AD. Am. J. Respir. Crit. Care Med. 1994; 149:A805(Abstr).

    Google Scholar 

  42. Wershil BK, Furuta GT, Lavigne JA, Choudhury AR, Wang ZS and Galli SJ. J. Immunol. 1995; 154:1391.

    PubMed  CAS  Google Scholar 

  43. Fruman DA, Bierer BE, Benes JE, Burakoff SJ, Austen KF and Katz HR. J. Immunol. 1995; 154:1846.

    PubMed  CAS  Google Scholar 

  44. Hogaboam CM, Bissonnette EY, Chin BC, Befus AD and Wallace JL. Gastroenterology. 1993; 104:122.

    PubMed  CAS  Google Scholar 

  45. Leal-Berumen I, O’Byrne P, Gupta A, Richards CD and Marshall JS. J. Immunol. 1995; 154:4, 59.

    Google Scholar 

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Authors and Affiliations

  1. Pulmonary Research Group Department of Medicine, University of Alberta, Edmonton Alberta, Canada, T6G 2S2

    Tong-Jun Lin, Antonio Enciso, Elyse Y. Bissonnette, Agnes Szczepek & A. Dean Befus

Authors
  1. Tong-Jun Lin
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  2. Antonio Enciso
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  3. Elyse Y. Bissonnette
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  4. Agnes Szczepek
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  5. A. Dean Befus
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Editor information

Editors and Affiliations

  1. University of Manitoba, Winnipeg, Manitoba, Canada

    Alec Sehon  & Kent T. HayGlass  & 

  2. Institute of General and Experimental Pathology, Vienna, Austria

    Dietrich Kraft

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© 1996 Springer Science+Business Media New York

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Lin, TJ., Enciso, A., Bissonnette, E.Y., Szczepek, A., Befus, A.D. (1996). Cytokine and Drug Modulation of TNFα in Mast Cells. In: Sehon, A., HayGlass, K.T., Kraft, D. (eds) New Horizons in Allergy Immunotherapy. Advances in Experimental Medicine and Biology, vol 409. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5855-2_40

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  • DOI: https://doi.org/10.1007/978-1-4615-5855-2_40

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7684-2

  • Online ISBN: 978-1-4615-5855-2

  • eBook Packages: Springer Book Archive

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