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Immunomodulation with T Cell Reactive Peptides

  • Chapter
New Horizons in Allergy Immunotherapy

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 409))

Abstract

The tremendous advances made in the identification and characterization of major environmental allergens over the last decade have made it possible to design therapies which are targeted to specific points in the allergic cascade. Proposed therapies include those which modulate either the activity or the production of cytokines, the binding of IgE to FcεRI on effector cells or the production of IgE antibodies. Considerable attention also has been given to treatments which directly modulate allergen-specific T cell responses(1–3). This concept has been realized in the therapeutic treatment of allergies with soluble allergenic extracts. Immunotherapy in this form has proven to be efficacious(4–6) and in some studies, clinical benefits have been correlated directly with downregulation of allergen specific T cell responses, such as T cell proliferation and cytokine production(7–11).

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Authors and Affiliations

  1. ImmuLogic Pharmaceutical Corporation, 610 Lincoln Street, Waltham, Massachusetts, 02154, USA

    Barbara P. Wallner & Mohammad Luqman

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  1. Barbara P. Wallner
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  2. Mohammad Luqman
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Editors and Affiliations

  1. University of Manitoba, Winnipeg, Manitoba, Canada

    Alec Sehon  & Kent T. HayGlass  & 

  2. Institute of General and Experimental Pathology, Vienna, Austria

    Dietrich Kraft

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Wallner, B.P., Luqman, M. (1996). Immunomodulation with T Cell Reactive Peptides. In: Sehon, A., HayGlass, K.T., Kraft, D. (eds) New Horizons in Allergy Immunotherapy. Advances in Experimental Medicine and Biology, vol 409. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5855-2_32

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  • DOI: https://doi.org/10.1007/978-1-4615-5855-2_32

  • Publisher Name: Springer, Boston, MA

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  • Online ISBN: 978-1-4615-5855-2

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