Abstract
Ovomucoid is the major egg antigen, and is composed of 3 domains (domain I: residues 1–64, domain II: residues 65–130, domain III: residues 131–186). In this study, we generated T cell lines and clones from 3 egg allergic patients (TK, PB, and XM) in order to characterize ovomucoid domain specificity and cell cytokine profile after stimulation with ovomucoid. Ovomucoid domain specificity was determined by measuring the proliferative response to each of the highly purified ovomucoid domains. Cytokine specific mRNA production was determined by reverse transcription polymerase chain reaction (RT-PCR).
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© 1996 Springer Science+Business Media New York
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Eigenmann, P.A., Huang, S.K., Ho, D.G., Sampson, H.A. (1996). Human T Cell Clones and Cell Lines Specific to Ovomucoid Recognize Different Domains and Consistently Express IL-5. In: Sehon, A., HayGlass, K.T., Kraft, D. (eds) New Horizons in Allergy Immunotherapy. Advances in Experimental Medicine and Biology, vol 409. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5855-2_29
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DOI: https://doi.org/10.1007/978-1-4615-5855-2_29
Publisher Name: Springer, Boston, MA
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