Abstract
The only causal treatment for allergic diseases currently available is hyposenzitization alias specific immunotherapy (SIT). The treatment is basically the injection of the causative agent i.e. an aqueous extract of the allergen source in question.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Secrist H, Chelen CJ, Wen Y, Marshall JD, Umetsu DT. Allergen immunotherapy decreases interleukin-4 production in CD4+ T cells from allergie individuals. J Exp Med 1993; 178:2123
Rafnar T, Griffith IJ, Kuo M, Bond JF, Rogers BL, Klapper DG. Cloning of Amb a I (Antigen E), the major allergen family of short ragweed pollen. J Biol Chem 1991;266:1229–1236.
Breiteneder H, Ferreira F, Reikerstorfer A, Duchene M, Valenta R, Hoffmann-Sommergruber K, Ebner C, Beritenbach M, Kraft D, Scheiner O. Complementary DNA cloning and expression in E. coli of Ain g I, the major allergen of alder (Alnus glutionosa). J Allergy Clin Immunol 1992;90:909–917.
Breiteneder H, Pettenburger K, Bito A, Valenta R, Kraft D, Rumpold H, Scheiner O, Breitenbach M. The gene coding for the major birch pollen allergen Bet v I is highly homologous to a pea disease resistance gene. EMBO J 1989;8:1935–1938.
Breiteneder H, Ferreira F, Hoffmann-Sommergruber K, Ebne C, Breitenbach M, Rumpold H, Kraft D, Scheiner O. Four recombinant isoforms of Cor a I, the major allergen of hazel pollen show different IgE-binding properties. Eur J Biochem 1993;212:355–362.
Larsen JN, Straman P, Ipsen H. PCR based cloning and sequencing of genes encoding the tree pollen major allergen Car b I from Carpinus betulus (hornbeam). Mol Immunol 1992;29:730–711.
van der Heijden FL, van Neerven RJJ, van Katwijk M, Bos JB, Kapsenberg ML. Serum IgE-facilitated allergen presentation in atopic disease. J Immunol 1993; 150:3643–3650.
Yssel H, Johnson KE, Schneider PV, Wideman J, Terr A, Kastelein, De Vries JE. T cell activation including epitopes of the house dust mite allergen Der p I. J Immunol 1992; 148:738–745.
O’Brien MR, Thomas W, Tait DB. An immunogenetic analyses of T-cell reactive regions of the major allergen from the house dust mite, Der p I, with recombinent truncated fragments. J Allergy Clin Immunol 1994;93:628–634.
Higgins AJ, Thorpe JC, Hayball DJ, O’Hehir ER, Lamb RJ. Overlapping T-cell epitopes in the group I allergen of Dermatophagoides species restricted by HLA-DP and HLA-DR class II molecules. J Allergy Clin Immunol 1994;93:891–899.
van Neerven RJJ, van de Pol MM, van Milligen FJ, Jansen HM, Aalberse RC, Kapsenberg ML. Characterization of cat dander-specific T lymphocytes from atopic patients. J Immunol 1994;224:717–722.
Moffat MF, Hill MR, Cornelis F, Schou C, Faux JA, Young RP, James AL, Ryan G, le Souef P, Musk AW, Hopkin JM, Cookson WOCM. Genetic linkage of T-cell receptor afpha/delta complex to specific IgE responses. Lancet 1994;343:1597–1600.
Young RP, Dekker JW, Wordsworth BP, Schou C, Pile KD, Matthiesen F, Rosenberg WMC, Bell JI, Hopkin JM, Cookson WOMC. HLA-DR and HLA-DP genotypes and immunoglobulin E responses to common major allergens. Clin Exp Allergy 1994;24:431–439.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer Science+Business Media New York
About this chapter
Cite this chapter
Schou, C. (1996). Advantages and Disadvantages of Recombinant Allergens and Peptides for Specific Immunotherapy. In: Sehon, A., HayGlass, K.T., Kraft, D. (eds) New Horizons in Allergy Immunotherapy. Advances in Experimental Medicine and Biology, vol 409. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5855-2_18
Download citation
DOI: https://doi.org/10.1007/978-1-4615-5855-2_18
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-7684-2
Online ISBN: 978-1-4615-5855-2
eBook Packages: Springer Book Archive