Skip to main content

Advantages and Disadvantages of Recombinant Allergens and Peptides for Specific Immunotherapy

  • Chapter
New Horizons in Allergy Immunotherapy

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 409))

Abstract

The only causal treatment for allergic diseases currently available is hyposenzitization alias specific immunotherapy (SIT). The treatment is basically the injection of the causative agent i.e. an aqueous extract of the allergen source in question.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Secrist H, Chelen CJ, Wen Y, Marshall JD, Umetsu DT. Allergen immunotherapy decreases interleukin-4 production in CD4+ T cells from allergie individuals. J Exp Med 1993; 178:2123

    Article  PubMed  CAS  Google Scholar 

  2. Rafnar T, Griffith IJ, Kuo M, Bond JF, Rogers BL, Klapper DG. Cloning of Amb a I (Antigen E), the major allergen family of short ragweed pollen. J Biol Chem 1991;266:1229–1236.

    PubMed  CAS  Google Scholar 

  3. Breiteneder H, Ferreira F, Reikerstorfer A, Duchene M, Valenta R, Hoffmann-Sommergruber K, Ebner C, Beritenbach M, Kraft D, Scheiner O. Complementary DNA cloning and expression in E. coli of Ain g I, the major allergen of alder (Alnus glutionosa). J Allergy Clin Immunol 1992;90:909–917.

    Article  PubMed  CAS  Google Scholar 

  4. Breiteneder H, Pettenburger K, Bito A, Valenta R, Kraft D, Rumpold H, Scheiner O, Breitenbach M. The gene coding for the major birch pollen allergen Bet v I is highly homologous to a pea disease resistance gene. EMBO J 1989;8:1935–1938.

    PubMed  CAS  Google Scholar 

  5. Breiteneder H, Ferreira F, Hoffmann-Sommergruber K, Ebne C, Breitenbach M, Rumpold H, Kraft D, Scheiner O. Four recombinant isoforms of Cor a I, the major allergen of hazel pollen show different IgE-binding properties. Eur J Biochem 1993;212:355–362.

    Article  PubMed  CAS  Google Scholar 

  6. Larsen JN, Straman P, Ipsen H. PCR based cloning and sequencing of genes encoding the tree pollen major allergen Car b I from Carpinus betulus (hornbeam). Mol Immunol 1992;29:730–711.

    Article  Google Scholar 

  7. van der Heijden FL, van Neerven RJJ, van Katwijk M, Bos JB, Kapsenberg ML. Serum IgE-facilitated allergen presentation in atopic disease. J Immunol 1993; 150:3643–3650.

    PubMed  Google Scholar 

  8. Yssel H, Johnson KE, Schneider PV, Wideman J, Terr A, Kastelein, De Vries JE. T cell activation including epitopes of the house dust mite allergen Der p I. J Immunol 1992; 148:738–745.

    PubMed  CAS  Google Scholar 

  9. O’Brien MR, Thomas W, Tait DB. An immunogenetic analyses of T-cell reactive regions of the major allergen from the house dust mite, Der p I, with recombinent truncated fragments. J Allergy Clin Immunol 1994;93:628–634.

    Article  PubMed  Google Scholar 

  10. Higgins AJ, Thorpe JC, Hayball DJ, O’Hehir ER, Lamb RJ. Overlapping T-cell epitopes in the group I allergen of Dermatophagoides species restricted by HLA-DP and HLA-DR class II molecules. J Allergy Clin Immunol 1994;93:891–899.

    Article  PubMed  CAS  Google Scholar 

  11. van Neerven RJJ, van de Pol MM, van Milligen FJ, Jansen HM, Aalberse RC, Kapsenberg ML. Characterization of cat dander-specific T lymphocytes from atopic patients. J Immunol 1994;224:717–722.

    Google Scholar 

  12. Moffat MF, Hill MR, Cornelis F, Schou C, Faux JA, Young RP, James AL, Ryan G, le Souef P, Musk AW, Hopkin JM, Cookson WOCM. Genetic linkage of T-cell receptor afpha/delta complex to specific IgE responses. Lancet 1994;343:1597–1600.

    Article  Google Scholar 

  13. Young RP, Dekker JW, Wordsworth BP, Schou C, Pile KD, Matthiesen F, Rosenberg WMC, Bell JI, Hopkin JM, Cookson WOMC. HLA-DR and HLA-DP genotypes and immunoglobulin E responses to common major allergens. Clin Exp Allergy 1994;24:431–439.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer Science+Business Media New York

About this chapter

Cite this chapter

Schou, C. (1996). Advantages and Disadvantages of Recombinant Allergens and Peptides for Specific Immunotherapy. In: Sehon, A., HayGlass, K.T., Kraft, D. (eds) New Horizons in Allergy Immunotherapy. Advances in Experimental Medicine and Biology, vol 409. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5855-2_18

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-5855-2_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7684-2

  • Online ISBN: 978-1-4615-5855-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics