Abstract
The potential of pulsed neutron diffraction in structural determination of biological materials is discussed. The problems and potential solutions in this area are outlined, with reference to both current and future sources and instrumentation. The importance of developing instrumentation on pulsed sources in emphasised, with reference to the likelihood of future expansion in this area. The possibilities and limitations of single crystal, fiber and powder diffraction in this area are assessed.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Deriu, A., (1993). The power of quasielastic neutron scattering to probe biophysical systems. Physica B, 183:331–342.
Deriu, A., Cavatorta, F., Cabrini, D., Carlile, C.J., & Middendorf, H.D., (1993). Water dynamics in biopolymer gels by quasielastic neutron scattering. Europhysics Letts., 24:351–357.
Deriu, A., Cavatorta, F., Moze, O., & diCola, D., (1995). Distribution of water in a highly hydrated fibre of K hyaluronate. ISIS Annual Report 1995, Vol. II, p A461.
Eastoe, J., Steytler, D.C., Robinson, B.H., & Heenan, R.K., (1994). Pressure induced structural changes in water-in-propane microemulsions. J. Chem. Soc. Faraday Trans., 90:121–3127.
Ibberson, R.M., & Prager, M., (1995). The ab initio structure determination of dimethylacetylene using high resolution neutron powder diffraction. Acta Cryst., B51:71–76.
Ibberson, R.M., David, W.I.F., & Prager, M., (1992). Accurate determination of hydrogen atom positions in toluene by neutron powder diffraction. J. Chem. Soc. Chem. Comm., 1992:1438–1439.
Konig, S., Sackmann, E., Richter, D., Zorn, R., Carlile, C.J., & Bayerl, T.M., (1994). Molecular dynamics of water in oriented DPPC multilayers studied by quasielastic neutron scattering and deuterium NMR relaxation. J. Chem. Phys., 100:3307–3316.
Kroon-Batenberg, L., Schreurs, A.M.M., & Wilson, C.C., (1994). Structure determination of cellulose II by fibre diffraction. ISIS Annual Report 1994, Vol. II, p A434.
Lehmann, A., Luger, P., Lehmann, C.W., & Ibberson, R.M., (1994). Oxalic acid dihydrate—an accurate low temperature structural study using high resolution neutron powder diffraction. Acta Cryst., B50:344–348.
Lehmann, M.S., & David, W.I.F., (1992). Report of the Crystallography Working Group. In Instrumentation and Techniques for the European Spallation Source, p. CRYST-22, editor A. D. Taylor, Rutherford Appleton Laboratory Report, RAL-92–040.
Meyer, D.F., Nealis, A.S., Bruckdorfer, K.R., & Perkins, S.J., (1995). Characterisation of the structure of polydisperse human low density lipoprotein by neutron scattering. Biochem. J., 310:407–415.
Naumann, C., Dietrich, C., Lu, J.R., Thomas, R.K., Rennie, A.R., Penfold, J., & Bayerl, T.M., (1994). Structure of mixed monolayers of dipalmitoylglycerophosphocholine and polyethylene-glycol monododecyl ether at the air-water interface. Langmuir, 10:1919–1925.
Penfold, J., & Thomas, R.K., (1990). The application of the specular reflection of neutrons to the study of surfaces and interfaces. J. Phys. Condensed Matter, 2:1369–1412.
Rhodes, N.J., Boram, A.J., Johnson, M.W., Mott, E.M., & Wardle, A.G., (1994). ISIS neutron detectors. In ICANS-XII, Rutherford Appleton Laboratory Report, RAL-94–025, Vol. I, pp. 185–199.
Ross, D.K., (1993). OSIRIS—Cold Neutron Spectrometer and Diffractometer. Proposal of a UK Collaborative Research Group. University of Salford.
Schoenborn, B.P., (editor) (1984). Neutrons in Biology (Basic Life Sciences Vol. 27, A. Hollaender, general editor). Plenum, New York.
Taylor, A.D., (1984). SNS moderator performance predictions. Rutherford Appleton Laboratory Report, RAL-84–120.
Wilson, C.C., (1990). The data analysis of reciprocal space volumes. In Neutron Scattering Data Analysis 1990, pp. 145–163, editor M.W. Johnson, IOP Conference Series 107. Adam Hilger, Bristol.
Wilson, C.C., (1993). The development and performance of position-sensitive detectors at ISIS. In Neutrons, X-rays and Gamma Rays: Imaging Detectors, Material Characterisation Techniques and Applications, pp. 226–234, editors J.M. Carpenter and D.F.R. Mildner, SPIE Conference Proceedings 1737, San Diego.
Wilson, C.C., (1995a). A guided tour of ISIS—the UK spallation neutron source. Neutron News, 6:27–34.
Wilson, C.C., (1995b). Monitoring phase transitions using a single data frame in neutron time-of-flight Laue diffraction. J. Appl. Cryst., 28:7–13.
Wilson, C.C., (1996). Improving the extraction of reflection intensities in single crystal time- of-flight diffraction using a peak profile fitting procedure. J Appl. Cryst., submitted.
Winter, R., Christmann, M.-H., Böttner, M., Thiyagarajan, P., & Heenan, R.K., (1991). The influence of the local anaesthetic tetracaine on the temperature and pressure dependant phase behaviour of model biomembranes. Ber. Bunsenges. Phys. Chem., 95:811–820.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer Science+Business Media New York
About this chapter
Cite this chapter
Wilson, C.C. (1996). The Potential for Biological Structure Determination with Pulsed Neutrons. In: Schoenborn, B.P., Knott, R.B. (eds) Neutrons in Biology. Basic Life Sciences, vol 64. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5847-7_6
Download citation
DOI: https://doi.org/10.1007/978-1-4615-5847-7_6
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-7680-4
Online ISBN: 978-1-4615-5847-7
eBook Packages: Springer Book Archive