Abstract
Confocal microscopy in conjunction with fluorescent probes have greatly facilitated the study of antimicrotubule drugs such as vinblastine, taxol and estramustine, and have been particularly useful in the characterization of drug resistant phenotypes associated with these and other drugs. By elucidating drug resistance mechanisms, ways of circumventing them can then be sought. This article will focus on structural, morphological and drug efflux studies aimed ultimately at uncovering how cancer cells develop resistance to the drug, estramustine.
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© 1996 Springer Science+Business Media New York
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Helt, AM., Kruh, G.D., Tew, K.D. (1996). The Use of Fluorescent Probes in Characterizing Drug Resistance in Cultured Cells. In: Kohen, E., Hirschberg, J.G. (eds) Analytical Use of Fluorescent Probes in Oncology. NATO ASI Series, vol 286. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5845-3_36
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DOI: https://doi.org/10.1007/978-1-4615-5845-3_36
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