Abstract
Cytochromes P450 play key roles in pharmacology and toxicology, because they are the key enzymes in the metabolism of exogenous chemicals, e.g. drugs and pollutants, and of endogenous chemicals, e.g steroids. Cytochromes P450 are hemoproteins with Fe as the central atom.They are membrane bound enzymes either anchored in the endoplasmatic reticulum adjacent to electron delivering cytochrome P450 reductase or in the mitochondrial membrane adjacent to ferredoxin reductase. They catalyze thousands of oxidative and reductive reactions by using oxygen. These reactions may be grouped according to similarities (Guengerich, 1993).
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Doehmer, J., Schmalix, W.A., Greim, H. (1996). Cell Expression System in V79 Cells Transfected with Cytochrome P450 and its Performance in Metabolism Studies. In: Kohen, E., Hirschberg, J.G. (eds) Analytical Use of Fluorescent Probes in Oncology. NATO ASI Series, vol 286. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5845-3_28
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DOI: https://doi.org/10.1007/978-1-4615-5845-3_28
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