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Lysosomal Nucleic Acid and Phosphate Metabolism and Related Metabolic Reactions

  • Chapter
Biology of the Lysosome

Part of the book series: Subcellular Biochemistry ((SCBI,volume 27))

Abstract

Lysosomes are a major intracellular site for the degradation of nucleic acids. Under conditions of nutritional deprivation, for example, approximately 65% of total rat liver cytoplasmic RNA is degraded per day, with 70–85% of this turnover occurring within the lysosomal compartment (Lardeux and Mortimore, 1987; Lardeux et al., 1987, 1988; Heydrick et al., 1991). Lysosomes contain an active repertoire of hydrolytic enzymes capable of completely degrading large amounts of nucleic acids to their basic constituents. In this chapter, the properties of the enzymes involved in lysosomal metabolism of nucleic acids and phosphates are described. The reader is also referred to earlier reviews by Barrett (1972) and Vaes (1973). In addition to the enzymes involved in lysosomal nucleic acid and phosphate metabolism, the role of lysosomes in the metabolism of cobalamin, folic acid polyglutamate, and coenzyme A are also discussed.

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  1. Department of Internal Medicine, Division of Nephrology, The University of Michigan Medical Center, Ann Arbor, MI, 48109, USA

    Ronald L. Pisoni

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  1. Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    John B. Lloyd  & Robert W. Mason  & 

  2. Nemours Research Programs, Wilmington, Delaware, USA

    John B. Lloyd  & Robert W. Mason  & 

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Pisoni, R.L. (1996). Lysosomal Nucleic Acid and Phosphate Metabolism and Related Metabolic Reactions. In: Lloyd, J.B., Mason, R.W. (eds) Biology of the Lysosome. Subcellular Biochemistry, vol 27. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5833-0_9

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  • DOI: https://doi.org/10.1007/978-1-4615-5833-0_9

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