Abstract
The ability of radiation therapy to cure cancer depends in part on its capacity to completely eradicate the localized disease without causing severe normal tissue injury. There is evidence that the escalation of dose targeted at the tumor would lead to an increase in local control and consequently to an improvement in survival. However, current levels of dose are limited by the tolerances of intervening normal tissues. Three-dimensional conformal radiation therapy (3D CRT) is now widely accepted as an important means of achieving higher tumor dose without concomitant increases in normal tissue doses.
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References
Mackie TR, Holmes TW, Swerdloff S, Reckwerdt PJ, Deasy JO, Yang J, Paliwal BR, Kinsella TJ. 1993. Tomotherapy: A new concept for the delivery of conformai radiotherapy. Med Phys 20:1709–1719.
Mohan R. 1995. Field shaping for three-dimensional conformai radiation therapy and multi-leaf collimation. Semin Radiat Oncol 5:86–99.
Mohan R. 1990. Secondary field shaping, asymmetrical collimators and Multileaf Collimators. Woodbury, NY: American Institute of Physics, Proceedings of AAPM Summer School, Kansas University, Lawrence, Kansas, pp. 307–345.
Wang X, Spirou S, LoSasso T, Chui CS, Mohan R. 1996. Dosimetric verification of an intensity modulated treatment. Med Phys 23:317–328.
Chui CS, LoSasso T, Spirou S. 1994. Dose calculations for photon beams with intensity modulation generated by dynamic jaw or multi-leaf collimations. Med Phys 21:1237–1243.
Chui CS, Mohan R. 1993. Algorithms for dynamic jaws and multi-leaf collimators, II — Fluence distribution (abstr). Med Phys 20:885.
Wu Q, Mohan R, Stein J, Wang X, Yang J. 1996. The impact of leaf width of MLC on intensity-modulated 3DCRT of prostate (abstr). Med Phys 23:1170–1170.
Mageras GS, Podmaniczky K, Mohan R. 1992. A model for computer controlled delivery of 3D conformai treatments. Med Phys 19:945–954.
Fraass BA, McShan DL, Kessler ML, Matrone GM, Lewis JD, Weaver TA. 1995. A computer-controlled conformai radiotherapy system I: Overview. Int J Radiat Oncol Biol Phys 33: 1139–1157.
Kessler ML, McShan DL, Fraass BA. 1995. A computer-controlled conformai radiotherapy system. III: Graphical simulation and monitoring of treatment delivery. Int J Radiat Oncol Biol Phys 33:1173–1180.
Austin-Seymour M, Caplan R, Russell K, Laramore G, Jacky J, Wootton P, Hummel S, Lindsley K, Griffin T. 1994. Impact of a multileaf collimator on treatment morbidity in localized carcinoma of the prostate. Int J Radiat Oncol Biol Phys 30:1065–1071.
Du MN, Yu CX, Symons M, Yan D, Taylor R, Matter RC, Gustafson G, Martinez A, Wong JW. 1995. A multileaf collimator field prescription preparation system for conventional radiotherapy. Int J Radiat Oncol Biol Phys 32: 513–520.
Klein EE, Harms WB, Low DA, Willcut V, Purdy JA. 1995. Clinical implementation of a commercial multileaf collimator: Dosimetry, networking, simulation and quality assurance. Int J Radiat Oncol Biol Phys 33:1195–1208.
LoSasso TJ, Chui CS, Kutcher GJ, Leibel SA, Fuks Z, Ling CC. 1993. The use of a multi-leaf collimator for conformai radiotherapy of carcinomas of the prostate and nasopharynx. Int J Radiat Oncol Biol Phys 25:161–170.
Powlis WD, Smith AR, Cheng E, Galvin JM, Villari F, Bloch P, Kligerman MM. 1993. Initiation of multileaf collimator conformai radiation therapy. Int J Radiat Oncol Biol Phys 25:171–179.
Mohan R, Wang X, Jackson A, Bortfeld T, Boyer AL, Kutcher GJ, Leibel SA, Fuks Z, Ling CC. 1994. The potential and limitations of the inverse radiotherapy technique. Radiother Oncol 32:232–248.
Convery DJ, Rosenbloom ME. 1992. The generation of intensity-modulated fields for conformai radiotherapy by dynamic collimation. Phys Med Biol 37:1359–1374.
Bortfeld T, Kahler DL, Waldron TJ, Boyer AL. 1994. X-ray field compensation with multileaf collimators. Int J Radiat Oncol Biol Phys 28: 723–730.
Spirou SV, Chui CS. 1994. Generation of arbitrary fluence profiles by dynamic jaws or multileaf collimators. Med Phys 21:1031–1041.
Mackie TR, Holmes TW, Reckwerdt PJ, Yang J, Swerdloff S, Deasy JO, DeLuca PM Jr, Paliwal BR, Kinsella TJ. Tomotherapy: A proposal for a dedicated computer-controlled delivery and verification system for conformai radiotherapy. (Christie Hospital NHS Trust, Manchester, UK, Proceedings of XIth.)
Carol MP. 1995. Peacock: A system for planning and rotational delivery of intensity-modulated fields. Int J Imaging Syst Technol 6:56–61.
Yu CX. 1995. Intensity-modulated arc therapy with dynamic multileaf collimation: An alternative to tomotherapy. Phys Med Biol 40:1435–1449.
Burman C, Armstrong J, Brewster L, Leibel S, Mohan R, Fuks Z, Kutcher GJ. 1993. Dose distribution comparison for multi-leaf collimator and cerrobend shaped fields for 3-dimensional lung plans (abstr). Med Phys 20: 925–925.
Burman C, Leibel SA, Mohan R, Kutcher GJ, Fuks Z. 1994. Comparison of dose distributions for 3D brain plans with cerrobend and multi-leaf collimators (abstr). Med Phys 21:885.
Shentall GS, Crockford DJ, Fernandes EM, Mayles WPM. 1993. The application of a multileaf collimator to conformai therapy. Proceedings of ESTRO Physics Meeting, Prague, Czechoslovakia, p. 99.
Zhu Y, Boyer AL, Desobry GE. 1992. Dose distributions of x-ray fields as shaped with multileaf collimators. Phys Med Biol 37:163–174.
Mohan R, Wu Q, Wang X-H, Stein J. 1996. Intensity modulation optimization, lateral transport of radiation and margins. Med Phys, in press.
Mageras GS, Fuks Z, O’Brien J, Brewster LJ, Burman C, Chui CS, Leibel SA, Ling CC, Masterson ME, Mohan R, Kutcher GJ. 1994. Initial clinical experience with computer-controlled conformai radiotherapy of the prostate using a 50-MeV medical microtron. Int J Radiat Oncol Biol Phys 30:971–978.
McShan DL, Fraass BA, Kessler ML, Matrone GM, Lewis JD, Weaver TA. 1995. A computer-controlled conformai radiotherapy system. II: Sequence processor. Int J Radiat Oncol Biol Phys 33:1159–1172.
Balter JM, Martel MK, Sandler HM, Ross DA, Forster KM, McShan DL, Fraass BA, Ten Haken RK. 1995. Clinical implementation of radio-surgery using a multileaf collimator and a computer controlled radiotherapy system (abstr). Int J Radiat Oncol Biol Phys 32:169–169.
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Mohan, R., Mageras, G., Wu, Q. (1998). Computer-Controlled Delivery of 3D Conformal Radiation Treatments. In: Mittal, B.B., Purdy, J.A., Ang, K.K. (eds) Advances in Radiation Therapy. Cancer Treatment and Research, vol 93. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5769-2_3
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DOI: https://doi.org/10.1007/978-1-4615-5769-2_3
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