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Maturation of fatty acid and carbohydrate metabolism in the newborn heart

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Molecular and Cellular Effects of Nutrition on Disease Processes

Part of the book series: Developments in Molecular and Cellular Biochemistry ((DMCB,volume 26))

Abstract

During fetal life, myocardial ATP is derived predominantly from glycolysis and lactate oxidation. Following birth, a rapid maturational increase in fatty acid oxidation occurs along with a decline in glycolytic and lactate oxidative rates, thus changing the major source of myocardial ATP production. This shift in energy substrate preference occurs in response to changes in the circulating substrate content of newborn plasma with the onset of suckling, and is also due to alterations in circulating levels of hormones, such as insulin and glucagon. Important changes in subcellular regulatory mechanisms of both fatty acid and carbohydrate metabolism in the heart also characterize this response. This review deals with recent advances in the understanding of these subcellular mechanisms which regulate this important shift in myocardial energy metabolism, with particular emphasis on the molecular events occurring in the heart during the transition from fetal to newborn life. (Mol Cell Biochem 188: 49–56, 1998)

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References

  1. Fisher DJ: Oxygenation and metabolism in the developing heart. Semin Prenatal 8: 217–225, 1984

    CAS  Google Scholar 

  2. Rolph TP, Jones CT: Metabolism during fetal life: A functional assessment of metabolic development. Physiol Rev 65: 357–430, 1985

    PubMed  Google Scholar 

  3. Lopaschuk GD, Collins-Nakai RL, Itoi T: Developmental changes in energy substrate use in the heart. Cardiovasc Res 26: 1172–1180, 1992

    Article  PubMed  CAS  Google Scholar 

  4. Werner JC, Sicard, RE: Lactate metabolism of isolated perfused fetal and newborn pig hearts. Pediatr Res 22: 552–556, 1987

    Article  PubMed  CAS  Google Scholar 

  5. Fisher DJ, Heymann MA, Rudolph AM: Myocardial oxygen and carbohydrate consumption in fetal lambs in utero and in adult sheep. Am J Physiol 238 (Heart Circ Physiol 7): H399–H405, 1980

    PubMed  CAS  Google Scholar 

  6. Fisher DJ, Heymann MA, Rudolph AM: Myocardial consumption of oxygen and carbohydrates in newborn sheep. Pediatr Res 15: 843–846, 1981

    Article  PubMed  CAS  Google Scholar 

  7. Rolph TP, Jones CT: Regulation of glycolytic flux in the heart of the fetal guinea pig. J Dev Physiol 5: 31–49, 1983

    PubMed  CAS  Google Scholar 

  8. Werner JC, Sicard RE, Schuler HG: Palmitate oxidation by isolated working fetal newborn pig hearts. Am J Physiol 256 (Endocrine Metab 19): E315–E321, 1989

    PubMed  CAS  Google Scholar 

  9. Itoi T, Lopaschuk GD: Calcium improves mechanical function and carbohydrate metabolism following ischemia in isolated bi-ventricular working hearts from immature rabbits. J Mol Cell Cardiol 28: 1501–1514, 1996

    Article  PubMed  CAS  Google Scholar 

  10. Lopaschuk GD, Spafford MA, Marsh DR: Glycolysis in predominant source of myocardial ATP production immediately after birth. Am J Physiol 261: H1698–H1705, 1991

    PubMed  CAS  Google Scholar 

  11. Ascuitto RJ, Ross-Ascuitto NT, Chen V, Downing SE: Ventricular function and fatty acid metabolism in neonatal piglet heart. Am J Physiol 256: H9–H15, 1989

    PubMed  CAS  Google Scholar 

  12. Comline RS, Silver M: Some aspects of fetal and uteroplacental metabolism in cows with indwelling umbilical and uterine vascular catheters. J Physiol (Lond) 260: 571–586, 1976

    CAS  Google Scholar 

  13. Phelps RL, Metzger BE, Freinkel N: Carbohydrate metabolism in pregnancy. XVII. Diurnal profiles of plasma glucose, insulin, free fatty acids, triglycerides, cholesterol and individual acids in the late normal pregnancy. Am J Obstet Gynecol 140: 730–736, 1969

    Google Scholar 

  14. Medina JM: The role of lactate as an energy substrate for the brain during the early neonatal period. Biol Neonate 48: 237–244, 1985

    Article  PubMed  CAS  Google Scholar 

  15. Girard J, Ferre P, Pegorier JP, Duee PH: Adaptations of glucose and fatty acid metabolism during perinatal period and suckling-weaning transition. Physiol Rev 72: 507–562, 1992

    PubMed  CAS  Google Scholar 

  16. Knopp RH, Warm MR, Charles D, et al.: Lipoprotein metabolism in pregnancy, fat transport to the fetus and effects of diabetes. Biol Neonate 50: 297–317, 1986

    Article  PubMed  CAS  Google Scholar 

  17. Warshaw JB, Terry ML: Cellular energy metabolism during fetal development. II Fatty acid oxidation by the developing heart. J Cell Biol 44: 354–360, 1970

    Article  PubMed  CAS  Google Scholar 

  18. Warshaw JB: Cellular energy metabolism during fetal development. IV. Fatty acid activation, acyl tranferase and fatty acid oxidation during development of the chick and rat. Dev Biol 28: 537–544, 1

    Article  PubMed  CAS  Google Scholar 

  19. Goodwin CW, Mela L, Deutsch C, Forster RE, Miller LD, Delivoria-Papadopoulous M: Development and adaptation of heart mitochondria respiratory chain function in fetus and newborn. Adv Exp Biol 75: 713–719, 1976

    Article  CAS  Google Scholar 

  20. Dallman PR, Schwart HC: Cytochrome concentration during rat and guinea-pig development. Pediatrics 33: 106–110, 1964

    PubMed  CAS  Google Scholar 

  21. Glatz JFC, Veerkamp JH: Postnatal development of palmitate oxidation and mitochondrial enzyme activities in rat cardiac and skeletal muscles. Biochim Biphys Acta 711: 327–335, 1982

    Article  CAS  Google Scholar 

  22. Werner JC, Whitman V, Musselman J, Schuler HG: Perinatal changes in mitochondrial respiration of the rabbit heart. Biol Neonate 42: 208–216, 1982

    Article  PubMed  CAS  Google Scholar 

  23. Fisher DA, Dussault JH, Sack J, Chopra J: Ontogenesis of hypot-thalamic-pituitary-thyroid function and metabolism in man, sheep and rat. Recent Prog Horm Res 33: 59–107, 1977

    Google Scholar 

  24. Bassett JM, Alexander G: Insulin, growth hormone and corticosteroids in neonatal lambs. Normal concentrations and the effect of cold. Biol Neonate 17: 112–125, 1971

    CAS  Google Scholar 

  25. Leturque A, Revelli JP, Haugwel S, Kande J, Girard J: Hyperglycemia and hyperinsulinemia increase glucose utilization in fetal rat tissue. Am J Physiol 260: E588–E593, 1991

    PubMed  CAS  Google Scholar 

  26. Schroeder RE, Doma Medina CL, Das UG, Sivitz WI, Devaskar SU: Effect of maternal diabetes on fetal rat myocardial and skeletal muscle glucose transporters. Pediatr Res 41: 11–19, 1997

    Article  PubMed  CAS  Google Scholar 

  27. Postic C, Leturque A, Prinz RL, Maulard P, Loizeau M, Granner DK, Girard J: Development and regulation of glucose transporter and hexokinase expression in rat. Am J Physiol 266: E548–E559, 1994

    PubMed  CAS  Google Scholar 

  28. Poole RC, Halestrap AP: Transport of lactate and other mono-carboxylates across mammalian plasma membranes. Am J Physiol 264: C761–C782, 1993

    PubMed  CAS  Google Scholar 

  29. Bristow J, Bic DM, Langer LG: Regulation of adult and fetal myocardial phosphofructokinase. J Biol Chem 262: 2172–2175, 1987

    Google Scholar 

  30. Barnie SE, Harris P: Myocardial enzyme activities in guinea pigs during development. Am J Physiol 233(6) H707–H710, 1977

    Google Scholar 

  31. Ohtsuka T, Gilbert RD: Cardiac enzyme activities in fetal and adult pregnant and non pregnant sheep exposed to high-altitude ischemia. J Appl Physiol 79(4): 1286–1289, 1995

    PubMed  CAS  Google Scholar 

  32. McGarry JD, Foster DW: Regulation of hepatic fatty acid oxidation and ketone body production. Annu Rev Biochem 49: 395–420, 1980

    Article  PubMed  CAS  Google Scholar 

  33. Lopaschuk GD, Witters LA, Itoi T, Barr R, Barr A: Acetyl CoA carboxylase involvement in the rapid maturation of fatty acid oxidation in the newborn rabbit heart. J Biol Chem 269: 25871–25878, 1994

    PubMed  CAS  Google Scholar 

  34. Saddik M, Gamble J, Witters LA, Lopaschuk GD: Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart. J Biol Chem 268: 25836–25845, 1993

    PubMed  CAS  Google Scholar 

  35. Brown NF, Weis BC, Husti JE, Foster DW, McGarry JD: Mitochondria carnitine palmitoyltransferase 1 isoform switching in the developing rat heart. J Biol Chem 270(15) 8952–8957, 1995

    Article  PubMed  CAS  Google Scholar 

  36. Xia Y, Buja M, McMillin JB: Change in expression of heart carnitine palmitoyltransferase 1 isoforms with electrical stimulation of cultured rat neonatal cardiac myocytes. J Biol Chem 271: 12082–12087, 1996

    Article  PubMed  CAS  Google Scholar 

  37. Makinde AO, Gamble J, Lopaschuk GD: Upregulation of 5′AMP activated protein kinase is responsible for the increase in myocardial fatty acid oxidation rates following birth in the newborn rabbit. Circ Res 80(4) 482–489, 1997

    Article  PubMed  CAS  Google Scholar 

  38. Kudo N, Barr AJ, Barr RL, Desai S, Lopaschuk GD: High rates of fatty acid oxidation following reperfusion of ischemic hearts are associated with a decrease in malonyl CoA levels due to an increase in 5 AMP-activated protein kinase inhibition of acetyl CoA carboxylase. J Biol Chem 270: 17513–17520, 1995

    Article  PubMed  CAS  Google Scholar 

  39. Beri RK, Marley AK, See CG, Sopwith WF, Aguan K, Carling D, Scott J, Carey F: Molecular cloning, expression and chromosomal localisation of human AMP-activated protein kinase. FEBS Lett 356: 117–121, 1994

    Article  PubMed  CAS  Google Scholar 

  40. Aguan K, Scott J, See CG, Sarkar NH: Characterization and chromosomal localization of the human homologue of a rat AMP-activated protein kinase-encoding gene: A major regulator of lipid metabolism in mammals. Gene 149: 345–350, 1994

    Article  PubMed  CAS  Google Scholar 

  41. Hawley SA, Davidson M, Woods A, Davies SP, Beri RJ, Carling D, Hardie DG: Characterization of the AMP activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP activated protein kinase. J Biol Chem 271: 27879–27887, 1996

    Article  PubMed  CAS  Google Scholar 

  42. Makinde AO, Lopaschuk GD: Stimulating 5′AMP activated protein kinase increases fatty acid oxidation in newborn rabbit hearts. J Mol Cell Cardiol 28(6): A179, 1996

    Google Scholar 

  43. Haystead TAJ, Moore F, Cohen P, Hardie G: Roles of the AMP-activated and cyclic-AMP-dependent protein kineses in the adrenaline-induced inactivation of acetyl-CoA carboxylase in rat adipocytes. Eur J Biochem 187: 199–205, 1990

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Cardiovascular Research Group, Lipid and Lipoprotein Research Group, Departments of Pediatrics and Pharmacology, Faculty of Medicine, The University of Alberta, Canada

    A-Olufemi Makinde, Paul F. Kantor & Gary D. Lopaschuk

Authors
  1. A-Olufemi Makinde
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  2. Paul F. Kantor
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  3. Gary D. Lopaschuk
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Editor information

Editors and Affiliations

  1. Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre, 351 Tache Avenue, Winnipeg, Manitoba, Canada, R2H 2A6

    Grant N. Pierce

  2. Department of Internal Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara Kanagawa 228, Japan

    Tohru Izumi (Professor and Chairman) (Professor and Chairman)

  3. Medizinische Forschung Philipps University of Marburg, Karl-von-Frisch-Str., 135033, Marburg, Germany

    Heinz Rupp

  4. INRA, Lipides Membranaires et Fonctions Cardiovasculaires Faculté des Sciences Pharmaceutiques et Biologiques, 4 Av de l’Observatoire, 75270, Paris Cedex 06, France

    Alain Grynberg

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© 1998 Springer Science+Business Media Dordrecht

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Makinde, AO., Kantor, P.F., Lopaschuk, G.D. (1998). Maturation of fatty acid and carbohydrate metabolism in the newborn heart. In: Pierce, G.N., Izumi, T., Rupp, H., Grynberg, A. (eds) Molecular and Cellular Effects of Nutrition on Disease Processes. Developments in Molecular and Cellular Biochemistry, vol 26. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5763-0_6

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  • DOI: https://doi.org/10.1007/978-1-4615-5763-0_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7641-5

  • Online ISBN: 978-1-4615-5763-0

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