Summary
Recent reports have shown that angiotensin-converting enzyme inhibitors have a role in cardiac remodeling and have beneficial effects on congestive heart failure. Several studies have described alterations in sarcoplasmic reticulum gene expression in the failing heart. These results indicate that calcium homeostasis in myocytes may be disturbed in congestive heart failure. The present study examines the effects of long-term treatments with the angiotensin-converting enzyme inhibitor Enalapril and Ang II subtype 1 receptor antagonist TCV-116 on the morphological changes in the extracellular matrix, progressive left ventricular dysfunction in cardiomyopathic hamsters. Between age 5–20 weeks, 24 BIO53.58 hamsters (model of dilated cardiomyopathy) received 10mg/kg per day orally either of TCV-116 or no treatment. Between age 5–30 weeks, 24 BIO53.58 hamsters (model of dilated cardiomyopathy) received 20mg/kg per day orally either of Enalapril or no treatment. During the study period, cardiac function was assessed by echocardiography in a noninvasive manner. At 20 or 30 weeks of age, each heart was fixed with 10% formalin, embedded in paraffin, and serial sections were stained with Gomori’s aldehyde fuchsin using the Masson-Goldner method. High framerate ultrasonoscopic echocardiograms revealed that the left ventricular percent fractional shortening (%FS) tended to improve in the Enalapril group (22 ± 4% vs 20 ± 3%) and TCV-116 group (24 ± 4% vs 21 ± 4%). The fibrous tissue volume significantly decreased in Enalapril group (25.2 ± 0.5 mm3, P < 0.05) compared with the untreated group (27.6 ± 2.3mm3). TCV-116 did not significantly decrease the fibrous tissue volume. Enalapril can prevent cardiac remodeling, but TCV-116 is not as effective as Enalapril. Enalapril may nevertheless, suppress fibrosis.
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Kawaguchi, H., Watanabe, M., Kitabatake, A. (1998). Effects of Angiotensin II Receptor Antagonist on Cardiac Remodeling in Cardiomyopathic Hamster Hearts. In: Dhalla, N.S., Zahradka, P., Dixon, I.M.C., Beamish, R.E. (eds) Angiotensin II Receptor Blockade Physiological and Clinical Implications. Progress in Experimental Cardiology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5743-2_42
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DOI: https://doi.org/10.1007/978-1-4615-5743-2_42
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