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Effects of Captopril on Myocardial Oxidative Stress Changes in Post-Mi Rats

  • Chapter
Angiotensin II Receptor Blockade Physiological and Clinical Implications

Part of the book series: Progress in Experimental Cardiology ((PREC,volume 2))

Summary

Changes in oxidative stress as indicated by the redox ratio as well as lipid peroxidation were characterized in rat hearts at different time points, subsequent to myocardial infarction (MI). In the severe heart failure stage at 16 weeks of post-MI, oxidative stress was significantly increased. Treatment with afterload reducing drugs, captopril or prazosin, started at 4 weeks post-MI and continued up to 16 weeks, resulted in a significant modulation of the oxidative stress changes with an improved hemodynamic function. It is suggested that the improved prognosis in MI patients with afterload reduction reported earlier may involve an improvement of the antioxidant reserve coupled with a reduction in the oxidative stress in the infarcted heart.

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Authors and Affiliations

  1. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, Winnipeg, Canada

    Neelam Khaper, Michael F. Hill, Julieta Pichardo & Pawan K. Singal

  2. Department of Physiology, Faculty of Medicine University of Manitoba, Winnipeg, Canada

    Neelam Khaper, Michael F. Hill, Julieta Pichardo & Pawan K. Singal

Authors
  1. Neelam Khaper
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  2. Michael F. Hill
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  3. Julieta Pichardo
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  4. Pawan K. Singal
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Editor information

Editors and Affiliations

  1. Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla Ph.D., M.D. (Hon.) (Distinguished Professor and Director MRC Group in Experimental Cardiology), Peter Zahradka Ph.D. (Associate Professor), Ian M. C. Dixon Ph.D. (Assistant Professor) & Robert E. Beamish M.D. (Professor Emeritus) (Distinguished Professor and Director MRC Group in Experimental Cardiology),  (Associate Professor),  (Assistant Professor) &  (Professor Emeritus)

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© 1998 Springer Science+Business Media New York

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Khaper, N., Hill, M.F., Pichardo, J., Singal, P.K. (1998). Effects of Captopril on Myocardial Oxidative Stress Changes in Post-Mi Rats. In: Dhalla, N.S., Zahradka, P., Dixon, I.M.C., Beamish, R.E. (eds) Angiotensin II Receptor Blockade Physiological and Clinical Implications. Progress in Experimental Cardiology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5743-2_39

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  • DOI: https://doi.org/10.1007/978-1-4615-5743-2_39

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7631-6

  • Online ISBN: 978-1-4615-5743-2

  • eBook Packages: Springer Book Archive

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