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Angiotensin II Receptor Blockade Physiological and Clinical Implications pp 141–151Cite as

Angiotensin Receptor Antagonists and Cardiovascular Remodeling

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Part of the book series: Progress in Experimental Cardiology ((PREC,volume 2))

Summary

Angiotensin (Ang) II is one of the key hormones involved in cardiovascular homeostasis. It has potent vasoconstrictor effects and is directly involved in the vascular and cardiac remodeling observed in response to chronic or acute hypertension. Two major Ang II receptor subtypes, AT1 and AT2, have been described, and their roles in vivo and in vitro have now been investigated using nonpeptidic antagonists, losartan and PD123319, which block AT1 and AT2 receptors respectively. The aim of this review is to focus on in vivo data to better define the respective functions of the AT1 and AT2 receptor subtypes. In adult rats, the AT1 receptor subtype does not trigger trophic effects directly in cardiomyocytes, whereas the AT2 receptor may have a major trophic role in smooth muscle cells.

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Authors and Affiliations

  1. INSERM U 127, INSERM U141, IFR Circulation, Université D. Diderot, Paris Cedex, France

    K. Sabri, C. Chassagne, B. Lévy, J.L. Samuel & L. Rappaport

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  1. K. Sabri
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  2. C. Chassagne
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  3. B. Lévy
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  4. J.L. Samuel
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  5. L. Rappaport
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Editor information

Editors and Affiliations

  1. Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla Ph.D., M.D. (Hon.) (Distinguished Professor and Director MRC Group in Experimental Cardiology), Peter Zahradka Ph.D. (Associate Professor), Ian M. C. Dixon Ph.D. (Assistant Professor) & Robert E. Beamish M.D. (Professor Emeritus) (Distinguished Professor and Director MRC Group in Experimental Cardiology),  (Associate Professor),  (Assistant Professor) &  (Professor Emeritus)

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Sabri, K., Chassagne, C., Lévy, B., Samuel, J., Rappaport, L. (1998). Angiotensin Receptor Antagonists and Cardiovascular Remodeling. In: Dhalla, N.S., Zahradka, P., Dixon, I.M.C., Beamish, R.E. (eds) Angiotensin II Receptor Blockade Physiological and Clinical Implications. Progress in Experimental Cardiology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5743-2_12

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  • DOI: https://doi.org/10.1007/978-1-4615-5743-2_12

  • Publisher Name: Springer, Boston, MA

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