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Bioenergetics of the Cell: Quantitative Aspects pp 153–167Cite as

Molecular characterization of the creatine kinases and some historical perspectives

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Part of the book series: Developments in Molecular and Cellular Biochemistry ((DMCB,volume 25))

Abstract

Over the last 15 years, molecular characterization of the creatine kinase (CK) gene family has paralleled the molecular revolution of understanding gene structure, function, and regulation. In this review, we present a summary of advances in molecular analysis of the CK gene family with a few vignettes of historical interest. We describe how the muscle CK gene provided an essential model system to examine myogenic regulatory mechanisms, leading to the discovery of the binding site for the MyoD family of basic helix-loop-helix transcription factors essential in skeletal myogenesis and the characterization of the MEF2 family of factors with an A/T rich consensus binding site essential in skeletal myogenesis and cardiogenesis. Cloning and characterization of the four mRNAs and nuclear genes encoding the cytosolic CKs, muscle and brain CKs, and the mitochondrial (Mt) CKs, sarcomeric MtCK and ubiquitous MtCK, has allowed intriguing study of tissue-specific and cell-specific expression of the different CKs and analysis of structural, functional, regulatory, and evolutionary relationships among both the four CK proteins and genes. Current and future studies focus on understanding both cellular energetics facilitated by the CK enzymes, especially energy channelling from the site of production, the mitochondrial matrix and inner membrane, to various cytosolic foci of utilization, and regulation of MtCK gene expression at the cell and tissue-specific level as models of regulation of energy producing genes. (Mol Cell Biochem (Mol Cell Biochem 184: 153–167, 1998)

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Authors and Affiliations

  1. Departments of Pediatrics and Molecular Biology and Pharmacology, Washington University School of Medicine and St. Louis Children’s Hospital, 63110, St. Louis, MO, USA

    Wenning Qin, Zaza Khuchua, Judy Cheng, Jaime Boero, R. Mark Payne & Arnold W. Strauss

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  1. Wenning Qin
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  2. Zaza Khuchua
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  3. Judy Cheng
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  4. Jaime Boero
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  5. R. Mark Payne
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  6. Arnold W. Strauss
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Editor information

Editors and Affiliations

  1. Laboratories of Bioenergetics, Institute of Chemical and Biological Physics, Tallinn, Estonia

    Valdur A. Saks

  2. Cellular and Molecular Cardiology, U 446 INSERM, Chatenay-Malabry, France

    Renée Ventura-Clapier

  3. Laboratory of Bioenergetics, Joseph Fourier University, Grenoble, France

    Valdur A. Saks , Xavier Leverve  & André Rossi ,  & 

  4. Laboratory of Bioenergetics, Institute of Biochemistry and Cellular Genetics CNRS, Bordeaux, France

    Michel Rigoulet

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© 1998 Springer Science+Business Media Dordrecht

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Qin, W., Khuchua, Z., Cheng, J., Boero, J., Payne, R.M., Strauss, A.W. (1998). Molecular characterization of the creatine kinases and some historical perspectives. In: Saks, V.A., Ventura-Clapier, R., Leverve, X., Rossi, A., Rigoulet, M. (eds) Bioenergetics of the Cell: Quantitative Aspects. Developments in Molecular and Cellular Biochemistry, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5653-4_12

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  • DOI: https://doi.org/10.1007/978-1-4615-5653-4_12

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