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TNF-α and insulin resistance: Summary and future prospects

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Insulin Action

Part of the book series: Developments in Molecular and Cellular Biochemistry ((DMCB,volume 24))

Abstract

While the causes of obesity remain elusive, the relationship between obesity and insulin resistance is a well-established fact [1]. Insulin resistance is defined as a smaller than normal response to a certain dose of insulin, and contributes to several pathological problems of obese patients such as hyperlipidemia, arteriosclerosis and hypertension. Several pieces of evidence indicate that the cytokine tumor necrosis factor a (TNF-α) is an important player in the state of insulin resistance observed during obesity. In this review we will try to summarize what is known about the function of TNF-α in insulin resistance during obesity and how TNF-α interferes with insulin signaling. (Mol Cell Biochem 182: 169-175, 1998)

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Authors and Affiliations

  1. Dana Farber Cancer Institute, Harvard Medical School, MA, Boston, USA

    Pascal Peraldi & Bruce Spiegelman

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  1. Pascal Peraldi
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  2. Bruce Spiegelman
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  1. Centre Hospitalier de l’Université de Montreal Pavillion Hotel Dieu, 3840, Rue Saint-Urbain, Montreal, Quebec, H2W 1T8, Canada

    Ashok K. Srivastava

  2. Polypeptide Hormone Laboratory Strathcona Anatomy & Dentistry Building, 3640 University Street, Room W3, 15, Montreal, Quebec, H3A 2B2, Canada

    Barry I. Posner

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Peraldi, P., Spiegelman, B. (1998). TNF-α and insulin resistance: Summary and future prospects. In: Srivastava, A.K., Posner, B.I. (eds) Insulin Action. Developments in Molecular and Cellular Biochemistry, vol 24. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5647-3_18

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  • DOI: https://doi.org/10.1007/978-1-4615-5647-3_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7584-5

  • Online ISBN: 978-1-4615-5647-3

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