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Insulin Action pp 161–168Cite as

Genetic manipulation of insulin action and β-cell function in mice

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Part of the book series: Developments in Molecular and Cellular Biochemistry ((DMCB,volume 24))

Abstract

Transgenic and gene targeting approaches have now been applied to a number of genes in order to investigate the metabolic disorders that would result by manipulating insulin action or pancreatic β-cell function in the mouse. The availability of such mutant mice will allow in the future to develop animal models in which the pathophysiologies resulting from polygenic defects might be reconstituted and studied in detail. Such animal models hopefully will lead to better understanding of complex polygenic diseases such as non-insulin-dependent diabetes mellitus (NIDDM). (Mol Cell Biochem 182: 161-168, 1998)

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Authors and Affiliations

  1. Institut Cochin de Génétique Moléculaire, INSERM U257, Paris, France

    Betty Lamothe, Bertrand Duvillié, Nathalie Cordonnier, Anne Baudry, Susan Saint-Just, Danielle Bucchini, Jacques Jami & Rajiv L. Joshi

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  1. Betty Lamothe
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  1. Centre Hospitalier de l’Université de Montreal Pavillion Hotel Dieu, 3840, Rue Saint-Urbain, Montreal, Quebec, H2W 1T8, Canada

    Ashok K. Srivastava

  2. Polypeptide Hormone Laboratory Strathcona Anatomy & Dentistry Building, 3640 University Street, Room W3, 15, Montreal, Quebec, H3A 2B2, Canada

    Barry I. Posner

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Lamothe, B. et al. (1998). Genetic manipulation of insulin action and β-cell function in mice. In: Srivastava, A.K., Posner, B.I. (eds) Insulin Action. Developments in Molecular and Cellular Biochemistry, vol 24. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5647-3_17

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