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Insulin Action pp 135–141Cite as

Potential mechanism (S) involved in the regulation of glycogen synthesis by insulin

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Part of the book series: Developments in Molecular and Cellular Biochemistry ((DMCB,volume 24))

Abstract

Stimulation of glycogen synthesis is one of the major physiological responses modulated by insulin. Although, details of the precise mechanism by which insulin action on glycogen synthesis is mediated remains uncertain, significant advances have been made to understand several steps in this process. Most importantly, recent studies have focussed on the possible role of glycogen synthase kinase-3 (GSK-3) and glycogen bound protein P hosphatase-1 (PP-1G) in the activation of glycogen synthase (GS) — a key enzyme of glycogen metabolism. Evidence is also accumulating to establish a link between insulin receptor induced signaling pathway(s) and glycogen synthesis. This article summarizes the potential contribution of various elements of insulin signaling pathway such as mitogen activated protein K inase (MAPK), protein K inase B (PKB), and p hosphatidyl i nositol 3-k inase (PI3-K) in the activation of GS and glycogen synthesis. (Mol Cell Biochem 182: 135-141, 1998)

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  1. Research Center, CHUM, Hôtel-Dieu Campus, Department of Medicine, University of Montréal, Montréal Québec, Canada

    Ashok K. Srivastava & Sanjay K. Pandey

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  1. Ashok K. Srivastava
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  1. Centre Hospitalier de l’Université de Montreal Pavillion Hotel Dieu, 3840, Rue Saint-Urbain, Montreal, Quebec, H2W 1T8, Canada

    Ashok K. Srivastava

  2. Polypeptide Hormone Laboratory Strathcona Anatomy & Dentistry Building, 3640 University Street, Room W3, 15, Montreal, Quebec, H3A 2B2, Canada

    Barry I. Posner

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Srivastava, A.K., Pandey, S.K. (1998). Potential mechanism (S) involved in the regulation of glycogen synthesis by insulin. In: Srivastava, A.K., Posner, B.I. (eds) Insulin Action. Developments in Molecular and Cellular Biochemistry, vol 24. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5647-3_14

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  • DOI: https://doi.org/10.1007/978-1-4615-5647-3_14

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