Abstract
A novel platelet substitute Synthocytes™ is being developed for the treatment and prevention of bleeding in acute thrombocytopenia. Synthocytes™ are composed of microcapsules of human serum albumin (HSA) to which human fibrinogen is immobilised. The product is manufactured using virally inactivated human blood derived proteins and is formulated as a sterile pyrogen free lyophilised preparation. The potential advantages of Synthocytes™ over platelet transfusion include a reduced risk of blood borne virus transmission, no risk of alloimmunogenic reactions, an increased shelf life and therefore a more cost effective, more easily managed therapy.
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© 1998 Springer Science+Business Media Dordrecht
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Middleton, S.M. (1998). The Development of Synthocytes™, a Novel Platelet Substitute. In: Sibinga, C.T.S., Das, P.C., Fratantoni, J.C. (eds) Alternative Approaches to Human Blood Resources in Clinical Practice. Developments in Hematology and Immunology, vol 33. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5619-0_9
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DOI: https://doi.org/10.1007/978-1-4615-5619-0_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-7571-5
Online ISBN: 978-1-4615-5619-0
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