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Heart Cell Communication in Health and Disease pp 195–216Cite as

Cellular Electrical Uncoupling During Ischemia

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 200))

Abstract

In 1875 T.W. Engelmann wrote: "Solche Zellen, die whrend des Lebens mit Verlust ihrer eigenen physiologischen Individualitt mit anderen zu einem Individuum höherer Ordnung verschmolzen sind, erhalten beim Absterben ihre Individualitt zurück … Die Zellen leben zusammen, aber sterben einzeln". (1) In our translation: "Such cells, which during life, at the expense of their own identity, are joined with other cells to form an entity of higher order, regain their individuality when dying ... The cells live together, but die alone." Thus, Engelmann formulated on the one hand the concept that the normal heart functions as a syncytium, on the other hand that lethally injured cells become isolated from the rest of the heart, a phenomenon that later became known as "healing-over".

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Author information

Authors and Affiliations

  1. Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands

    Michiel J. Janse, Hanno L. Tan, Lukas R. C. Dekker & André G. Kléber

  2. Department of Clinical and Experimental Cardiology, Academic Medical Center, Interuniversity Cardiology Institute, The Netherlands

    Michiel J. Janse, Hanno L. Tan, Lukas R. C. Dekker & André G. Kléber

  3. Department of Physiology, University of Bern, Switzerland

    Michiel J. Janse, Hanno L. Tan, Lukas R. C. Dekker & André G. Kléber

Authors
  1. Michiel J. Janse
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  2. Hanno L. Tan
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  3. Lukas R. C. Dekker
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  4. André G. Kléber
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Editor information

Walmor C. De Mello Michiel J. Janse

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Janse, M.J., Tan, H.L., Dekker, L.R.C., Kléber, A.G. (1998). Cellular Electrical Uncoupling During Ischemia. In: De Mello, W.C., Janse, M.J. (eds) Heart Cell Communication in Health and Disease. Developments in Cardiovascular Medicine, vol 200. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5525-4_9

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  • DOI: https://doi.org/10.1007/978-1-4615-5525-4_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7525-8

  • Online ISBN: 978-1-4615-5525-4

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