Abstract
Oligodendrocyte progenitors (O-2A) require multiple signals to proliferate in culture. In the absence of serum or in medium containing low concentrations of serum, O-2A cells differentiate spontaneously into oligodendrocytes. During this process they lose the intermediate filament protein vimentin and the cell surface antigen A2B5; concomitantly, galactocerebroside (GC) appears on the cell surfaces and numerous branched cellular processes are extended, and later on myelin specific proteins, i.e. Wolfgram protein (CNP), myelin basic protein (MBP), myelin associated glycoprotein (MAG), and proteolipid protein (PLP) are expressed even in the absence of neurons (1).
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Richter-Landsberg, C., Hoppenstedt, W. (1997). Growth Regulation and Myelin Protein Expression in a Newly Established Permanent Glial Cell Line. In: Teelken, A., Korf, J. (eds) Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5405-9_40
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DOI: https://doi.org/10.1007/978-1-4615-5405-9_40
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