Abstract
Cerebral autoregulation is commonly defined as the sum of adaptive mechanisms of the brain in response to a variety of functional, i.e. physiological, and non-functional, i.e. pathological conditions. Its primary goal is to maintain adequate delivery of substrates and removal of waste products of cerebral metabolism. Cerebral autoregulation therefore involves adaptive mechanisms at subcellular, cellular and intercellular levels as well as regulation of local, regional and global cerebral circulation (Bruce 73, Grubb 75, Harper 66, Lowell 71, McGillicuddy 78, Weinstein 64). Autoregulation also includes systemic responses of metabolism, respiration and circulation. All of those cerebral autoregulatory mechanisms may be severely impaired in head injured patients (Langfitt 65, McGillicuddy 78, Obrist 84).
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Scheufler, K.M., Thees, C., Steinberg, F., Zentner, J. (1997). NIR Reflexion Spectroscopy Based Oxygen Measurements During Intracranial Hypertension in Rabbits. In: Harrison, D.K., Delpy, D.T. (eds) Oxygen Transport to Tissue XIX. Advances in Experimental Medicine and Biology, vol 428. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5399-1_32
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