Abstract
The concentration and saturation of the main oxygen carrier of the blood—the haemoglobin—may be an important clinical factor to judge the oxygenation of tissue. The brain is very sensitive to under-oxygenation. So far, the measurement of absolute cerebral haemoglobin concentration by near infrared spectrophotometry (NIRS) has not taken into account the contribution of skull and skin, which causes an underestimation by a factor of 3 [Owen-Reece, 1996] in adults.
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Wolf, M. et al. (1997). Measurement of Absolute Cerebral Haemoglobin Concentration in Adults and Neonates. In: Harrison, D.K., Delpy, D.T. (eds) Oxygen Transport to Tissue XIX. Advances in Experimental Medicine and Biology, vol 428. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5399-1_31
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DOI: https://doi.org/10.1007/978-1-4615-5399-1_31
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