Abstract
Oxygen is an important component in tumors that influences the response to radiation therapy and certain forms of chemotherapy. Extensive work has demonstrated that the pO2 in human tumors cannot be predicted based on size, histological grade or type but must be meas-ured (1). Recent studies have confirmed that tumor pO2 correlates with the outcome of radia-tion therapy (2–4). One obvious treatment where individualization of treatment could be of value is during courses of radiation therapy. It has been postulated that fractionated radiation is successful because the tissue reoxygenates after initial doses of radiation and initially hy- poxic regions of tumors become more oxygenated and therefore respond better to subsequent doses. Different tumor types and different individual tumors reoxygenate at different times and to different extents. Accurate assessments of tumor pO2 that reflect the physiological status of the whole tumor could result in better treatments for solid tumors.
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References
P. W. Vaupel, Oxygenation of solid tumors. In Drug Resistance in Oncology (B. A. Teicher, Ed.), pp. 53–86. Marcel Dekker, New York, 1993.
M. Hockel, C. Knoop, K. Schlenger, B. Vorndran, E. Baussmann, M. Mitze, P. G. Knapstein and P. Vaupel, Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix. Radiother Oncol. 26, (1), 45–50(1993).
M. Hockel, K. Schlenger, M. Mitze, U. Schaffer and P. Vaupel, Hypoxia and radiation response in human tumors. Sem in Radiat Oncol 6, 3–9 (1996).
P. Okunieff, M. Hoeckel, E. P. Dunphy, K. Schlenger, C. Knoop and P. Vaupel, Oxygen tension distribu-tions are sufficient to explain the local response of human breast tumors treated with radiation alone. Int J Radiat Oncol Biol Phys. 26, (4), 631–6 (1993).
F. Goda, J. A. O’Hara, E. S. Rhodes, K. J. Liu, J. F. Dunn, G. Bacic and H. M. Swartz, Changes of oxygen tension in experimental tumors after a single dose of X-ray irradiation. Cancer Res. 55, (11), 2249–52 (1995).
J. A. O’Hara, F. Goda, K. J. Liu, G. A. Bacic, P. J. Hoopes and H. M. Swartz, The pO2 in a murine tumor after radiation: an in vivo electron paramagnetic resonance oximetry study. Radiat Res. 144, (2), 222–229 (1995).
P. E. James, O. Y. Grinberg, F. Goda, J. A. O’Hara and H. M. Swartz, Gloxy: An oxygen-sensitive coal for accurate measurement of low oxygen tensions in biological systems. Magn Reson Med. 38, 48–58 (1997).
P. R. Twentyman, J. M. Brown, J. W. Gray, A. J. Franko, M. A. Scoles and R. F. Kallman, A new mouse tu-mor model system (RIF-1) for comparison of endpoint studies. J Natl Canc Inst. 64, 595–604 (1980).
K. H. Clifton, R. C. Briggs and H. B. Stone, Quantitative radiosensitivity studies of solid carcinomas in vivo: methodology and effect of anoxia. J Natl Canc Inst. 36, 965–974 (1966).
E. Jones, B. Lyons, E. Douple, A. Filimonov and B. Dain, Response of a brachytherapy model using 125I in a murine tumor system. Radiat Res. 118, 112–130 (1989).
E. B. Douple, J. A. O’Hara and E. L. Jones, Paraplatin enhancement of radiation therapy in a murine tumor (MTG-B). In Anticancer Drug Research (K. Lapis S. Eckhardt, Ed.), pp. 71–80. Akademiai Kiado, Buda-pest, 1987.
F. Goda, K. J. Liu, T. Walczak, J. A. O’Hara and H. M. Swartz, In vivo oximetry using EPR and India ink. Magn Reson Med. 33, (2), 237–245 (1995).
H. M. Swartz, K. J. Liu, F. Goda and T. Walczak, India ink: A potential clinically applicable EPR oximetry probe. Magn Reson Med. 31, (2), 229–232 (1994).
J. F. Dunn, S. Ding, J. A. O’Hara, K. J. Liu, E. Rhodes, J. B. Weaver and H. M. Swartz, The apparent diffu-sion constant measured by MRI correlates with pO2 in a RIF-1 tumor. Magn Reson Med. 34, (4), 515–9 (1995).
G. Bacic, K. J. Liu, J. A. OߣHara, R. D. Harris, K. Szybinski, F. Goda and H. M. Swartz, Oxygen tension in a murine tumor: a combined EPR and MRI study. Magn Reson Med. 30, (5), 568–72 (1993).
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O’Hara, J.A. et al. (1997). Determining the Anatomic Position and Histological Effects in Murine Tumors of Gloxy an Oxygen-Sensitive Paramagnetic Material. In: Harrison, D.K., Delpy, D.T. (eds) Oxygen Transport to Tissue XIX. Advances in Experimental Medicine and Biology, vol 428. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5399-1_15
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DOI: https://doi.org/10.1007/978-1-4615-5399-1_15
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