Abstract
Colligin is a major glycoprotein in many cells and has been discovered several times by different approaches and hence given different names. Kurkinen et al. (1984) first found it as a collagen-binding protein in parietal endoderm cells and proposed the name‘colligin’ but it was later detected as a differentiation related protein in myoblasts (‘gp46’) (Cates et al., 1984) and as a heat shock responsive protein in chick fibroblasts (HSP47) (Nagata & Yamada, 1986). Sequencing later confirmed the identity of the various proteins. Each of the routes of discovery delivered clues about the function of the protein, leading eventually to the current idea of a role as a molecular chaperone in collagen synthesis.
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Ball, E.H., Jain, N., Sanwal, B.D. (1997). Colligin, A Collagen Binding Serpin. In: Church, F.C., Cunningham, D.D., Ginsburg, D., Hoffman, M., Stone, S.R., Tollefsen, D.M. (eds) Chemistry and Biology of Serpins. Advances in Experimental Medicine and Biology, vol 425. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5391-5_22
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DOI: https://doi.org/10.1007/978-1-4615-5391-5_22
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