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Plasminogen Activator Inhibitor Type-2

A Spontaneously Polymerizing Serpin that Exists in Two Topological Forms

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Book cover Chemistry and Biology of Serpins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 425))

Abstract

Plasminogen activator inhibitor type-2 (PAI-2) is a quite unusual Serpin. Unlike most other Serpins, which are secreted proteins with well characterized target proteinases and function, PAI-2 exists in both cytosolic and secreted forms; its physiological role is not well understood.

This work was supported by the Swedish Natural Science Foundation Research Grants NFR BU 8473-308.

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Authors and Affiliations

  1. Department of Medical Biochemistry and Biophysics, Umeå University, S-90187, Umeå, Sweden

    Tor Ny & Peter Mikus

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  1. Tor Ny
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  2. Peter Mikus
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Editor information

Editors and Affiliations

  1. University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA

    Frank C. Church

  2. University of California, Irvine, California, USA

    Dennis D. Cunningham

  3. Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan, USA

    David Ginsburg

  4. Duke University and Durham VA Medical Centers, Durham, North Carolina, USA

    Maureane Hoffman

  5. Late of Monash University, Clayton, Victoria, Australia

    Stuart R. Stone

  6. Washington University School of Medicine, St. Louis, Missouri, USA

    Douglas M. Tollefsen

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Ny, T., Mikus, P. (1997). Plasminogen Activator Inhibitor Type-2. In: Church, F.C., Cunningham, D.D., Ginsburg, D., Hoffman, M., Stone, S.R., Tollefsen, D.M. (eds) Chemistry and Biology of Serpins. Advances in Experimental Medicine and Biology, vol 425. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5391-5_12

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  • DOI: https://doi.org/10.1007/978-1-4615-5391-5_12

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