Skip to main content

Corneal Epithelial Rejection after Allograft Conjunctival Transplantation for Limbal Papilloma

A Case Report

  • Chapter
  • 179 Accesses

Abstract

The authors report a case of typical corneal epithelial rejection two months after allogenic limbal-conjunctival graft for a recurrent limbal-conjunctival papilloma in a 62- year-old female patient. The HLA donor-recipient pair was haploidentical (50% identity). This observation suggests a clear conjunctival epithelial transdifferentiation onto corneal epithelium. This is the first report, to the best of the authors’ knowledge, of allograft conjunctival transplantation for this disease and of corneal epithelial rejection after such a procedure. In this case, there was no rejection of the conjunctival graft, and corneal rejection was successfully treated with oral prednisone and topical 1% prednisolone.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. R.A. Thoft, Conjunctival transplantation. Arch. Ophthalmol. 95:1425 (1977).

    Article  PubMed  CAS  Google Scholar 

  2. R.A. Thoft, Keratoepithelioplasty. Am. J. Ophthalmol. 97:1 (1984).

    PubMed  CAS  Google Scholar 

  3. S. Kwitko, Marinho, D., Barcaro, S., et al., Allograft conjunctival transplantation for bilateral ocular surface disorders. Ophthalmology 102(7): 1020 (1995).

    PubMed  CAS  Google Scholar 

  4. R.R. Pfister, Corneal stem cell disease: concepts, limbal stem cells. CLAO J. 120(1): 64 (1994).

    Google Scholar 

  5. RJ-F Tsai, and Tseng, S.C.G., Human allograft limbal transplantation for corneal surface reconstruction. Cornea 13(5):389 (1994).

    Article  PubMed  CAS  Google Scholar 

  6. D.T.H. Tan, and Flicker, L.A., Limbal transplantation. Ophthalmology 103:29 (1996).

    PubMed  CAS  Google Scholar 

  7. S.C.G. Tseng, Chen, J.J.Y., Huang, A.J.W., et al., Classification of conjunctival surgeries for corneal diseases based on stem cell concept. Ophthalmol. Clin. North Am. 3:595 (1990).

    Google Scholar 

  8. M.J. Carvalho, Mourac, R.C., Cunha, M., et al., Limbal autografi transplantation for severe ocular burn. Arq. Bras. Oftalmol. 57:167 (1994).

    Google Scholar 

  9. K.R. Kenyon, and Tseng, S.C.G., Limbal autografi transplantation for ocular surface disorders. Ophthalmology 96:709 (1989).

    PubMed  CAS  Google Scholar 

  10. S. Kinoshita, Friend, J., and Thoft, R.A., Biphasic cell proliferation in transdifferentiation of conjunctival to corneal epithelium in rabbits. Invest. Ophthalmol. Vis. Sci. 24:1008 (1983).

    PubMed  CAS  Google Scholar 

  11. M.S. Shapiro, Friend, J., and Thoft, R.A., Corneal re-epithelialization from the conjunctiva. Invest. Ophthalmol. Vis. Sci. 21:135 (1981).

    PubMed  CAS  Google Scholar 

  12. S. Kinoshita, Kiorpes, T.C., Friend, J., and Thoft, R.A., Limbal epithelium in ocular surface wound healing. Invest. Ophthalmol. Vis. Sci. 23:73 (1982).

    PubMed  CAS  Google Scholar 

  13. R.A. Thoft and Friend, J., Biochemical transformation of regenerating ocular surface epithelium. Invest. Ophthalmol. Vis. Sci. 16:14 (1977).

    PubMed  CAS  Google Scholar 

  14. R.A. Thoft, Conjunctival surgery for corneal disease. In The Cornea: Scientific Foundations and Clinical Practice, Third Edition, G. Smolin and Thoft, R.A., eds., Boston, Little, Brown (1994).

    Google Scholar 

  15. R.J.F. Tsai, Sun, T.T., and Tseng, S.C.G., Comparison of limbal and conjunctival autografi transplantation in corneal surface reconstruction in rabbits. Ophthalmology 97:446 (1990).

    PubMed  CAS  Google Scholar 

  16. T.E. Clinch, Goins, K.M., and Cobo, L.M., Treatment of contact lens-related ocular surface disorders with autologous conjunctival transplantation. Ophthalmology 99:534 (1992).

    Google Scholar 

  17. P.W. Turgeon, Nauheim, R.C., Roat, M.I., et al., Indications for keratoepithelioplasty. Arch. Ophthalmol. 108:233 (1990).

    Article  PubMed  CAS  Google Scholar 

  18. R.A. Weise, Mannis, M.J., Vastine, D.W., et al., Conjunctival transplantation. Autologous and homologous grafts. Arch. Ophthalmol. 103:1736 (1985).

    Article  PubMed  CAS  Google Scholar 

  19. K. Tsubota, Toda, I., Saito, H., et al., Reconstruction of the corneal epithelium by limbal allograft transplantation for severe ocular surface disorders. Ophthalmology 102:1486 (1995).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer Science+Business Media New York

About this chapter

Cite this chapter

de Lima Bocaccio, F.J., Kwitko, S., Fridman, D., Duarte, J.R., Chies, M.A., Yaluk, J.B. (1997). Corneal Epithelial Rejection after Allograft Conjunctival Transplantation for Limbal Papilloma. In: Lass, J.H. (eds) Advances in Corneal Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5389-2_7

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-5389-2_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7460-2

  • Online ISBN: 978-1-4615-5389-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics